Role of mitochondrial dysfunction associated with mitochondria-associated endoplasmic reticulum membranes in Alzheimer's disease

doi:10.3877/cma.j.issn.1674-0785.2024.02.019

Abstract

Abstract:

Alzheimer's disease (AD) is a progressive neurodegenerative disease with clinical manifestations of cognitive dysfunction and behavioral impairment, imposing a heavy economic burden on families and society. Recent studies have revealed that mitochondria-associated endoplasmic reticulum membranes (MAM) have a significant correlation with early pathological changes of AD, such as mitochondrial dysfunction. MAM up-regulation can lead to intracellular mitochondrial dysfunction and structural changes, mainly including mitochondrial Aβ deposition, mitochondrial dynamics alternations, and mitochondrial autophagy, thus promoting the occurrence of AD. This article reviews the role of MAM-mediated mitochondrial dysfunction in the pathological changes of AD, providing new potential targets for the early treatment of AD and the delay of AD progression.

Key words: Alzheimer's disease, Mitochondria-associated endoplasmic reticulum membranes, Mitochondrial Aβ, Mitochondrial dynamics, Mitochondrial autophagy

Weiwei Yu, Guogao Zhang, Jun Wu, Jun Hu, Yining Huang, Jing Xu. Role of mitochondrial dysfunction associated with mitochondria-associated endoplasmic reticulum membranes in Alzheimer's disease[J]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(02): 223-230.

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