Management of neonatal respiratory distress syndrome: a brief introduction and evaluation of multinational guidelines/consensuses and RDS-NExT workshop consensus statements

doi:10.3877/cma.j.issn.1674-0785.2024.07.001

Abstract

Abstract:

Neonatal respiratory distress syndrome （RDS） is a common cause of neonatal respiratory distress. Although intervention strategies such as prenatal corticosteroids（ACS）， neonatal pulmonary surfactant （PS） replacement therapy， and advanced neonatal respiratory management have improved the prognosis of neonates with RDS， it remains one of the leading causes of morbidity and mortality in premature infants. In order to facilitate the management of neonatal RDS， multiple countries around the world have issued clinical management guidelines and expert consensuses， but there has been no consensus on these guidelines or consensuses. By giving a brief review of Avery ME and others’ research results and introducing the long process of discovering and recognizing RDS as well as the gradual evolution of diagnosis and treatment of RDS， this article emphasizes the etiology，classification， evaluation， and diagnosis of RDS， highlights the latest evidence based on multinational guidelines/consensuses， and provides a brief introduction and evaluation of the consensus statement of the RDS-Neonatal Expert Taskforce （RDS-NExT） in the United States.

Key words: Infant，newborn, Respiratory distress syndrome, Hyaline membrane disease, Management, Guideline, Consensus

Maojun Li, Binzhi Tang, Qing Wu, Qian Yang, Xiaoming Liang, Fulan Zou, Rong Huang, Changhui Chen. Management of neonatal respiratory distress syndrome: a brief introduction and evaluation of multinational guidelines/consensuses and RDS-NExT workshop consensus statements[J]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(07): 607-617.

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	日本	欧洲
RDS诊断	呼吸窘迫症状^a、需要FiO₂（＞0.3）、需要吸气压力（＞7 cm H₂O）、SMR（“中等”到“零”）和CXR^b的组合	主要根据呼吸窘迫症状^a和对FiO₂需求的临床评估
PS给药	诊断为RDS的患儿	CPAP或插管时需要FiO₂＞0.3的患儿

	日本	欧洲
RDS诊断	呼吸窘迫症状^a、需要FiO₂（＞0.3）、需要吸气压力（＞7 cm H₂O）、SMR（“中等”到“零”）和CXR^b的组合	主要根据呼吸窘迫症状^a和对FiO₂需求的临床评估
PS给药	诊断为RDS的患儿	CPAP或插管时需要FiO₂＞0.3的患儿

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