Abstract:

Objective

To explore the clinical diagnosis, treatment, and surgical efficacy for retroperitoneal paraganglioma.

Methods

The clinical data of 42 cases of retroperitoneal paraganglioma admitted to Peking University International Hospital from April 2015 to January 2024 were retrospectively analyzed, and their clinical characteristics, surgical efficacy, and prognosis were discussed.

Results

Of the 42 patients with retroperitoneal paraganglioma, 19 had functional catecholamine-secreting tumors before surgery, 15 had no obvious symptoms, and 8 had abdominal distension, abdominal pain, and back pain.Forty cases had a single tumor, and two had multiple tumors.Twenty-two cases had obvious fluctuation in blood pressure during operation.Thirty-eight cases achieved R0 or R1 excision, and four achieved R2 resection.Six cases underwent combined organ resection.The median maximum tumor diameter was 7 (range, 3～27) cm.Intraoperative blood loss was 800 (range, 50～4500) ml.There were 7 cases of postoperative complications.Compared with patients with stable blood pressure, those with intraoperative blood pressure fluctuation had significantly larger tumor size, more bleeding, and prolonged postoperative hospital stay (P＜0.05).After 3～68 months of follow-up, two patients had recurrence and one had distant metastasis.

Conclusion

Surgery is the main treatment method for retroperitoneal paraganglioma.Intraoperative blood pressure fluctuation increases the risk of surgery.Accurate preoperative assessment and adequate preoperative preparation can help reduce the risk of surgery.

Key words: Paraganglioma, Retroperitoneal neoplasms, Postoperative complications