Progress in applied research of pathogenesis of antisynthase syndrome and function of aminoacyl-tRNA synthetase

doi:10.3877/cma.j.issn.1674-0785.2024.10.010

Abstract

Abstract:

Antisynthetase syndrome (ASS) is a subtype of idiopathic inflammatory myopathy.Anti-aminoacyl-tRNA synthetase antibodies can be detected in the serum of ASS patients.ASS may clinically manifest as arthritis, myositis, and interstitial lung disease (ILD).ILD can also be the first manifestation of the ASS, but its pathogenesis is still not very clear.This paper summarizes the possible pathogenesis of ASS, several common target antigens and their functions, the role of anti-ARS antibodies, and the clinical characteristics of different antibodies, in order to help other clinicians understand the pathogenesis and clinical diagnosis and treatment of this disease.

Key words: Antisynthase syndrome, Interstitial lung disease, Aminoacyl-tRNA synthetase

Dan Xuan, Wenfeng Tan. Progress in applied research of pathogenesis of antisynthase syndrome and function of aminoacyl-tRNA synthetase[J]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(10): 943-948.

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