Advances in understanding of role of wound pathogens in wound healing and scar formation

doi:10.3877/cma.j.issn.1674-0785.2024.10.012

Abstract

Abstract:

Human skin wounds are contaminated by pathogens, which aggravate and prolong the inflammatory response.This can cause chronic or difficult wound healing, resulting in delayed wound healing and scar formation.Studies have found that Gram-negative (G^-) bacteria are the main pathogens causing chronic wound inflammation, delayed wound healing, and scar formation in chronic wound and burn wound infection.Lipopolysaccharide, a unique endotoxin of G^- bacteria, is the main inflammatory medium causing chronic wound inflammation.Therefore, reducing wound pathogen infection and chronic inflammatory response can greatly improve wound healing quality and prevent scar formation.This review describes the function, pathogenic characteristics, and mechanism of wound pathogens in wound healing and scar formation, and proposes that the control of pathogen infection in wounds is an effective strategy to promote wound healing and protect against scar formation, with an aim to lay a theoretical foundation and provide clinical guidance for the prevention and treatment of pathological scar.

Key words: Wound pathogens, Inflammation, Wound healing, Scar formation

Shan Shi, Zhigang Xu, Shuang Wei, Hao Guan, Jihong Shi. Advances in understanding of role of wound pathogens in wound healing and scar formation[J]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(10): 955-960.

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