Abstract:

Objective

To compare and analyze the sedation effect of applying remimazolam benzenesulfonate and propofol during rescue tracheal intubation in neurocritical patients.

Methods

A total of 114 neurocritical patients admitted to Wuhan Fourth Hospital from February 2024 to November 2024 were selected and divided into either a remimaazolam group (Group R; 57 cases) or propofol group (Group P;57 cases) according to the the sedative drug used, and the changes of vital signs, sedation effect, intubation evaluation, and the incidence of adverse reactions in the two groups were compared.

Results

Hemodynamic fluctuations during intubation were significantly smaller in the remimazolam group than in the propofol group(P＜0.05). The overall incidence of adverse reactions in the remimazolam group was 31.6%, which was significantly smaller than that of the propofol group (68.4%; P＜0.05). There was no significant difference in the success rate of first-dose sedation or the success rate of first intubation between the two groups. The time to loss of consciousness [(63.60±14.02)s vs (46.61±13.28)s, P＜0.05)] and intubation time [(37.44±11.18)s vs (33.02±8.14)s, P=0.017)] in the remazolam group were longer than those of the propofol group (P＜0.05),but no significant difference was seen in any of the choking body movements between the 2 groups(P＞0.05).

Conclusion

Remimazolam benzenesulfonate has the characteristics of fast onset of action,no injection pain, and not being easy to cause respiratory depression, and can provide similar intubation conditions as propofol with less hemodynamic impact, representing some advantages in rescue tracheal intubation in neurocritical patients.

Key words: Remimazolam, Neurocritical care, Intensive care, Tracheal intubation