Research progress of 5-hydroxytryptamine and ferroptosis-mediated septic cardiomyopathy

doi:10.3877/cma.j.issn.1674-0785.2025.08.009

Abstract

Abstract:

Sepsis can lead to multiple systemic complications, with myocardial injury being one of the most frequent and severe complications, and serving as a crucial prognostic marker in septic patients. Ferroptosis, a recently identified form of programmed cell death, has been shown to participate in the pathogenesis of septic cardiomyopathy (SCM). As an inflammatory mediator, 5-hydroxytryptamine (5-HT) has been demonstrated to promote sepsis progression, yet its precise mechanism in mediating cardiac injury via ferroptosis remains incompletely understood. This review systematically summarizes the mechanistic role of 5-HT in SCM, aiming to provide novel therapeutic targets and clinical strategies.

Key words: Sepsis, Ferroptosis, Myocardial injury, 5-hydroxytryptamine, Inflammatory response

Yi Zhou, Ronghua Huang, Zhengjiang Liu. Research progress of 5-hydroxytryptamine and ferroptosis-mediated septic cardiomyopathy[J]. Chinese Journal of Clinicians(Electronic Edition), 2025, 19(08): 612-617.

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