DeepSeek combined with three-dimensional simulation of coaxial multi-quadrant 125I particle implantation therapy for lung cancer

doi:10.3877/cma.j.issn.1674-0785.2025.10.007

Abstract

Abstract:

Objective

To analyze the efficacy of DeepSeek combined with three-dimensional (3D) digital imaging simulation technology in iodine-125 (¹²⁵I) seed implantation for lung cancer treatment.

Methods

This retrospective study involved 95 patients with lung malignancies who underwent ¹²⁵I seed implantation at Daqing Oilfield Hospital, Daqing, China from 2023 to 2025. The participants were divided into three groups: group A (n=33), which received preoperative standardized diagnosis/treatment planning using DeepSeek for dose calculation and risk prediction, combined with CT-based 3D reconstruction surgical simulation and coaxial single-needle ¹²⁵I seed implantation, group B (n=31), which underwent CT-based 3D reconstruction surgical simulation followed by conventional ¹²⁵I seed implantation, and group C (n=31), which received conventional preoperative management followed by standard ¹²⁵I seed implantation.

Results

Group A demonstrated significantly shorter operative time, reduced postoperative drainage tube indwelling duration, and shorter postoperative hospital stay compared to both group B and group C (P＜0.01). The incidence of postoperative hemoptysis in group A was lower than that in group C. Additionally, group A had a lower incidence of postoperative pneumothorax compared to groups B and C (P＜0.05).

Conclusion

Precise treatment planning and preoperative preparation significantly improve therapeutic outcomes by reducing operative time, postoperative complications, and hospital stay. As an emerging local treatment approach, ¹²⁵I seed implantation demonstrates superiority when combined with DeepSeek-based standardized preoperative management and 3D reconstruction technology, offering a less invasive and more targeted alternative compared to conventional methods.

Key words: DeepSeek, 3D digital imaging, Simulated surgery, ¹²⁵I, Lung cancer

Xuefeng Yang, Tao Sun, Lei Shi, Yuefeng Wang, Shiying Feng, Zhencai Zhang, Yingying Cui, Tianxiang Gu. DeepSeek combined with three-dimensional simulation of coaxial multi-quadrant ¹²⁵I particle implantation therapy for lung cancer[J]. Chinese Journal of Clinicians(Electronic Edition), 2025, 19(10): 772-778.

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URL: https://zhlcyszz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0785.2025.10.007

https://zhlcyszz.cma-cmc.com.cn/EN/Y2025/V19/I10/772

Figures/Tables 4

临床资料	A组（33例）	B组（31例）	C组（31例）
年龄（岁， $x ¯$ ±s）	60.79±6.64	61.85±7.23	58.71±7.6
性别[例（%）]
男性	17（51.52）	17（54.83）	18（58.06）
女性	16（48.49）	14（45.16）	13（41.93）
体质量指数（kg/m²， $x ¯$ ±s）	23.28±3.13	22.93±3.62	23.85±3.77
吸烟[例（%）]	19（57.58）	18（58.06）	20（64.52）
高血压[例（%）]	12（36.36）	11（35.48）	10（32.26）
糖尿病[例（%）]	9（27.27）	8（25.81）	6（19.35）
咯血[例（%）]	5（15.15）	5（16.13）	4（12.90）
咳嗽[例（%）]	18（54.55）	20（64.52）	19（61.29）
胸闷气短[例（%）]	18（54.55）	15（48.39）	16（51.61）
肿瘤直径（cm， $x ¯$ ±s）	2.53±0.7	2.62±0.93	2.75±0.87

临床资料	A组（33例）	B组（31例）	C组（31例）
年龄（岁， $x ¯$ ±s）	60.79±6.64	61.85±7.23	58.71±7.6
性别[例（%）]
男性	17（51.52）	17（54.83）	18（58.06）
女性	16（48.49）	14（45.16）	13（41.93）
体质量指数（kg/m²， $x ¯$ ±s）	23.28±3.13	22.93±3.62	23.85±3.77
吸烟[例（%）]	19（57.58）	18（58.06）	20（64.52）
高血压[例（%）]	12（36.36）	11（35.48）	10（32.26）
糖尿病[例（%）]	9（27.27）	8（25.81）	6（19.35）
咯血[例（%）]	5（15.15）	5（16.13）	4（12.90）
咳嗽[例（%）]	18（54.55）	20（64.52）	19（61.29）
胸闷气短[例（%）]	18（54.55）	15（48.39）	16（51.61）
肿瘤直径（cm， $x ¯$ ±s）	2.53±0.7	2.62±0.93	2.75±0.87

临床资料	A组（33例）	B组（31例）	C组（31例）
手术时间（min， $x ¯$ ±s）	22.79±6.85	26.88±7.42^*	32.68±11.61^&#
术中失血量（ml， $x ¯$ ±s）	2.76±1.39	2.87±1.43	3.0±1.55
术后咯血[例（%）]	15（45.45）	18（58.06）	23^*（74.19）
术后气胸[例（%）]	12（36.36）	19^*（29.03）	21^*（67.74）
术后引流时间（d）	0（0~2）	1（0~2）	3（0~8）^&a
肺部感染[例（%）]	5（15.15）	7（22.58）	6（19.35）
放射性肺炎[例（%）]	1（3.03）	0（0）	0（0）
镇痛药使用（d）	1（1~2）	1（1~2）	1（1~2）
术后住院（d）	3（2~4）	3（3~4.5）	7（4~11）^&a

临床资料	A组（33例）	B组（31例）	C组（31例）
手术时间（min， $x ¯$ ±s）	22.79±6.85	26.88±7.42^*	32.68±11.61^&#
术中失血量（ml， $x ¯$ ±s）	2.76±1.39	2.87±1.43	3.0±1.55
术后咯血[例（%）]	15（45.45）	18（58.06）	23^*（74.19）
术后气胸[例（%）]	12（36.36）	19^*（29.03）	21^*（67.74）
术后引流时间（d）	0（0~2）	1（0~2）	3（0~8）^&a
肺部感染[例（%）]	5（15.15）	7（22.58）	6（19.35）
放射性肺炎[例（%）]	1（3.03）	0（0）	0（0）
镇痛药使用（d）	1（1~2）	1（1~2）	1（1~2）
术后住院（d）	3（2~4）	3（3~4.5）	7（4~11）^&a

References 28

1	Howlader N, Forjaz G, Mooradian MJ, et al. The effect of advances in lung-cancer treatment on population mortality [J]. N Engl J Med, 2020, 383(7): 640-649.
2	Liu S, Chen Q, Guo L, et al. Incidence and mortality of lung cancer in China, 2008-2012 [J]. Chin J Cancer Res, 2018, 30(6): 580-587.
3	Chang S, Dai M, Ren JS, et al. Estimates and prediction on incidence, mortality and prevalence of lung cancer in China in 2008 [J]. Zhonghua Liu Xing Bing Xue Za Zhi 2012, 33(4): 391-394.
4	Zhang F, Wang J, Guo J, et al. Chinese expert consensus workshop report: Guideline for permanent iodine-125 seeds implantation of primary and metastatic lung tumors (2020 edition) [J]. J Cancer Res Ther, 2020, 16(7): 1549-1554.
5	Niu L, Zhou L, Xu K, et al. Combination of cryosurgery and Iodine-125 seeds brachytherapy for lung cancer [J]. J Thorac Dis, 2012, 4(5): 504-507.
6	Li Z, Hu Z, Xiong X, et al. A review of the efficacy and safety of iodine-125 seed implantation for lung cancer treatment [J]. Cancer Treat Res Commun, 2024, 41: 100844.
7	杨雪峰, 王岳峰, 孙涛等. 3D数字呈像模拟手术技术在胸腔镜下肺叶切除术中的应用[J]. 中国胸心血管外科临床杂志, 2019, 26(8): 784-788.
8	Zhou H, Niu L, Zhou L, et al. Cryosurgery combined with Iodine-125 seed implantation in the treatment of unresectable lung cancer [J]. Zhongguo Fei Ai Za Zhi, 2008, 11(6): 780-783.
9	Li W, Guan J, Yang L, et al. Iodine-125 brachytherapy improved overall survival of patients with inoperable stage Ⅲ/Ⅳ non-small cell lung cancer versus the conventional radiotherapy [J]. Med Oncol, 2015, 32(1): 395.
10	Guibin D, Xiaolan S, Wei Z, et al. Prediction of iodine-125 seed implantation efficacy in lung cancer using an enhanced CT-based nomogram model [J]. PLoS One, 2024, 19(11): e0313570.
11	Lu HB, Wang YQ, Liu X, et al. Effects of preoperative high-intensity interval training combined with team empowerment education in lung cancer patients with surgery: a quasi-experimental trial [J]. Cancer Nurs, 2024, 47(6): E368-E375.
12	Lee JH, Jeong JH, Ji W, et al. Comparative effectiveness of smartphone healthcare applications for improving quality of life in lung cancer patients: study protocol [J]. BMC Pulm Med, 2022, 22(1): 175.
13	Chen Y, Li X, Chen T, et al. Postoperative rehabilitation management self-efficacy and its relationship with symptoms in the patients with lung cancer: a latent profile analysis [J]. Asia Pac J Oncol Nurs, 2024, 11(9): 100554.
14	Zeng XS, Wang CT, Zhou H, et al. Low-dose three dimensional reconstruction of the femur with unit free-form deformation [J]. Medical Physics, 2014, 41(8): 081911.
15	Wang K, Huang C, Kao YJ, et al. Accelerating image reconstruction in three-dimensional optoacoustic tomography on graphics processing units [J]. Med Phys, 2013, 40(2): 023301.
16	Guimaraes P, Rodrigues P, Celorico D, et al. Three-dimensional segmentation and reconstruction of the retinal vasculature from spectral-domain optical coherence tomography [J]. J Biomed Opt, 2015, 20(1): 16006.
17	Lopez RE, Garcia JR, Sanchez AM, et al. Hybrid imaging (SPECT/computed tomography)with three- dimensional reconstruction: a new diagnostic tool for the study of low back pain after spinal fusion surgery [J]. Spine J, 2015, 15(2): 377-378.
18	Shi JS, Xia J, Wei YB, et al. Three-dimensional virtual reality simulation of periarticular tumors using dextroscope reconstruction and simulated surgery: a preliminary 10 case study [J]. Acta Orthop, 2014, 80(1): 132-138.
19	Stella F, Dolci G, Dell'Amore A, et al. Three-dimensional surgical simulation-guided navigation in thoracic surgery: a new approach to improve results in chest wall resection and reconstruction for malignant diseases [J]. Interact Cardiovasc Thorac Surg, 2014, 18(1): 7-12.
20	Zhang H, Ma X, Li B, et al. Research progress of three-dimensional printed customized prosthesis and its application in acetabular reconstruction of hip revision surgery [J]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2024, 38(11): 1414-1420. Chinese.
21	Zeng L, Zhu Y, Guo P. Meta-analysis of the effects of three-dimensional visualized medical techniques hepatectomy for liver cancer with and without the treatment of Sorafenib [J]. Evid Based Complement Alternat Med, 2022, 2022: 4507673.
22	Lin KC, Ko WC, Tsai YD, et al. Hemorrhage risk prediction after computed tomography-guided lung biopsy: clinical parameters and quantitative pulmonary vascular analysis [J]. J Formos Med Assoc, 2025, 124(1): 79-86.
23	Yang Y, Ma J, Peng Z, et al. Pneumothorax and pulmonary hemorrhage after C-arm cone-beam computed tomography-guided percutaneous transthoracic lung biopsy: incidence, clinical significance, and correlation [J]. BMC Pulmonary Medicine, 2024, 24(1): 33.
24	Vinikoor-Imler LC, Davis JA, Luben TJ. An ecologic analysis of county-level PM2.5 concentrations and lung cancer incidence and mortality [J]. Int J Environ Res Public Health, 2011, 8(6): 1865-1871.
25	Gibbs GW, Labrèche F, Busque MA, et al. Mortality and cancer incidence in aluminum smelter workers: a 5-year update [J]. J Occup Environ Med, 2014, 56(7): 739-764.
26	Howlader N, Forjaz G, Mooradian MJ, et al. The effect of advances in lung-cancer treatment on population mortality [J]. N Engl J Med, 2020, 383(7): 640-649.
27	李婛，凌国源，江山，等. 非小细胞肺癌软脑膜转移通过Ommaya囊注射与腰椎穿刺术给药方式疗效的比较[J]. 中华临床医师杂志(电子版), 2024,18(2): 128-132.
28	李林宇，崔世超，杨晓，等. 630 nm激光联合血卟啉衍生物治疗晚期支气管肺癌的近期临床疗效分析[J]. 中华临床医师杂志(电子版), 2024,18(2): 133-138.

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