The “National Health Commission of China：colorectal cancer diagnosis and treatment guidelines （2025 edition） ” builds upon evidence‑based medicine, integrating international cutting‑edge advancements and Chinese clinical practices to deepen and expand previous versions. This article presents a standardized and streamlined version, retaining the core diagnostic and therapeutic framework while highlighting newly added content such as “surgical treatment of anal canal cancer” and “new technologies and advancements in diagnosis and treatment.” It systematically summarizes the key points of five major sections: surgery, internal medicine, radiotherapy, imaging, and pathology, facilitating clinicians′ rapid grasp of the essence of the guidelines and promoting the standardization, precision, and homogenization of colorectal cancer diagnosis and treatment..