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Chinese Journal of Clinicians(Electronic Edition) ›› 2017, Vol. 11 ›› Issue (13): 1965-1969. doi: 10.3877/cma.j.issn.1674-0785.2017.13.001

Special Issue:

• Clinical Researches •     Next Articles

Correlation between plasma aldosterone concentration and pulse pressure in patients with essential hypertension in different positions

Xiaoguang Yao1, Jing Hong1, Mei Li1, Xiufang Li1, Junli Hu1, Delian Zhang1, Guijuan Chang1, Keming Zhou1, Nanfang Li1,()   

  1. 1. Hypertension Center of People’s Hospital of Xinjiang Uygur Autonomous Region, Hypertension Institute of Xinjiang Uygur Autonomous Region, Urumqi 830000, China
  • Received:2017-03-16 Online:2017-07-01 Published:2017-07-01
  • Contact: Nanfang Li
  • About author:
    Corresponding author: Li Nanfang, Email:

Abstract:

Objective

To investigate the correlation between plasma aldosterone concentration (PAC) and pulse pressure (PP) in patients with essential hypertension in different positions.

Methods

A total of 195 patients with hypertension were selected at the Hypertension Center of People′s Hospital of Xinjiang Uygur Autonomous Region from October 2008 to October 2010. All subjects successfully completed stimulation tests in the sitting, supine, and upright positions, and the blood pressure and PAC were measured in the three positions. According to the average pulse pressure, the patients were divided into either a normal PP group (PP < 40 mmHg) or a high PP group (PP ≥ 40 mmHg). Clinical indicators were compared between the two groups. The correlation between PP and aldosterone levels was analyzed.

Results

Serum potassium was significantly higher in the high PP group than in the normal PP group (P = 0.01). Correlation analysis showed that after adjustment of serum potassium, age, and sex, PP was positively correlated with PAC in all the three positions (upright: r = 0.235, P = 0.001; sitting: r = 0.220, P = 0.002; supine: r = 0.166, P = 0.021). Regardless of any position, the level of aldosterone was significantly higher in the high PP group than in the normal PP group. Average PP was significantly higher in patients with PAC > 12 ng/dl in the upright and sitting positions than in those with PAC ≤ 12 ng/dl. A logistics regression model was established by using PP ≥ 40 mmHg as the dependent variable, and age, blood potassium, body mass index, and aldosterone levels in the three position as independent variables. Regression analysis showed that serum K+ [OR = 0.043, 95% CI: 1.09 (1.00-1.12)] and PAC [OR = 0.025, 95% CI: 0.35 (0.13-0.88)] were risk factors for increased PP.

Conclusion

There is a positive correlation between serum PAC level and PP, regardless of body position. High level of PAC is a risk factor for arterial elasticity in patients with hypertension.

Key words: Plasma aldosterone, Essential hypertension, Pulse pressure, Different positions

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