Relationship between pathogenesis of chronic skin ulcer and overexpression of Ras and C-myc

doi:10.3877/cma.j.issn.1674-0785.2017.18.006

Chinese Journal of Clinicians(Electronic Edition) ›› 2017, Vol. 11 ›› Issue (18): 2237-2240. doi: 10.3877/cma.j.issn.1674-0785.2017.18.006

Special Issue: ；

• Basic Research • Previous Articles Next Articles

Relationship between pathogenesis of chronic skin ulcer and overexpression of Ras and C-myc

Rui Shen¹^,^†(), Jingming Zhang², Fenggang Zhang³, Ping Chen¹, Xueliang Du¹, Yongxuan Li¹, Bilai Liu¹, lin Deng¹, Hongmei Song⁴, Lusheng Xu⁴

^1. Department of Plastic and Cosmetic Surgery, First People’s Hospital of Foshan, Foshan 528000, China
^2. Department of Plastic Surgery, Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 450052, China
^3. Department of Burn and plastic Surgery, First People’s Hospital of Foshan, Foshan 528000, China
^4. Department of Hand and Foot Plastic Surgery, First People’s Hospital of Foshan, Foshan 528000, China

Received:2017-03-09 Online:2017-09-15 Published:2017-09-15
Contact: Rui Shen
About author:
Corresponding author: Shen Rui, Email: Shenruihaohao@163.com

Abstract

Abstract:

Objective

To explore the relationship between the abnormal overexpression of Ras and C-myc in chronic ulcers of the skin and the pathogenesis of squamous cell carcinoma (SCC) in Marjolin′s ulcer.

Methods

Ten tissue specimens of SCC in Marjolin′s ulcer, ten tissue specimens of chronic skin ulcer accompanied with pseudoepitheliomatous hyperplasia, ten tissue specimens of primary SCC, and five tissue specimens of normal skin were collected. The expression of Ras and C-myc in these specimens was detected by immunohistochemistry.

Results

Both Ras and C-myc were overexpressed in the tissues of SCC in Marjolin′s ulcer. The nuclear staining of Ras and C-myc was positive in some carcinoma cells. However, they were negatively expressed in normal skin tissue and primary SCC cells. They were also not expressed in the epithelial cells with atypical hyperplasia in chronic skin ulcer accompanied with pseudoepitheliomatous hyperplasia.

Conclusion

The abnormal expression of Ras and C-myc is closely related to the carcinogenesis in chronic ulcer.

Key words: Marjolin′s ulcer, Squamous cell carcinoma, Chronic skin ulcer, Ras, C-myc

Rui Shen, Jingming Zhang, Fenggang Zhang, Ping Chen, Xueliang Du, Yongxuan Li, Bilai Liu, lin Deng, Hongmei Song, Lusheng Xu. Relationship between pathogenesis of chronic skin ulcer and overexpression of Ras and C-myc[J]. Chinese Journal of Clinicians(Electronic Edition), 2017, 11(18): 2237-2240.

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References 14

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