Effect of CD74 expression on macrophage-placental trophoblast interaction in preeclampsia

doi:10.3877/cma.j.issn.1674-0785.2017.19.008

Abstract

Abstract:

Preeclampsia is a serious complication of pregnancy, mainly characterized by hypertension and proteinuria and other clinical manifestations. Severe cases can endanger the lives of mothers and infants. In recent years, studies have shown that preeclampsia is caused by a variety of factors, although the specific cause is not very clear. The balance of placental macrophage-trophoblast interactions plays an important role in the development of normal pregnancy. Normal expression of cluster of differentiation 74 (CD74) and MIF plays an important role in the interaction between placental macrophages and trophoblast cells, which is one of the focuses of current research. Here we will review the role of CD74 and MIF in placental macrophage-trophoblast interaction in preeclampsia in order to further explore the pathogenesis of this disease.

Key words: Macrophage-trophoblast cell interactions, CD74, MIF, Placenta formation, Preeclampsia

Tingting Wang, Jin Yan, Ying Zheng, Xiang Kong. Effect of CD74 expression on macrophage-placental trophoblast interaction in preeclampsia[J]. Chinese Journal of Clinicians(Electronic Edition), 2017, 11(19): 2289-2292.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhlcyszz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0785.2017.19.008

https://zhlcyszz.cma-cmc.com.cn/EN/Y2017/V11/I19/2289

References 23

[1]	王益群. 妊娠期高血压疾病相关影响因素及对妊娠结局影响的研究 [J]. 中华全科医学, 2015, 13(4): 602-605.
[2]	柯泉，曾利. 阿魏酸钠对子痫前期患者胎盘组织MIF及氧化应激的影响 [J]. 中国实验诊断学, 2015(1): 76-77.
[3]	Hariharan N, Shoemaker A, Wagner S. Pathophysiology of hypertension in preeclampsia [J]. Microvascular Research, 2016, 109: 34-37.
[4]	American College of Obstetricians and Gynecologists, Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ task force on hypertension in pregnancy [J]. Obstet Gynecol, 2013, 122: 1122-1131.
[5]	Rusterholz C, Hahn S, Holzgreve W. Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia [J]. Semin Immunopathol, 2007, 29: 151-162.
[6]	Przybyl L, Haase N, Golic M, et al. CD74-Downregulation of Placental Macrophage-Trophoblastic Interactions in Preeclampsia. [J]. Circulation Research, 2016, 115: 41-42.
[7]	Xu B, Nakhla S, Makris A, Hennessy A. TNF-α inhibits trophoblast integration into endothelial cellular networks [J]. Placenta. 2011, 32: 241-246.
[8]	赵然，姚伟娟. 巨噬细胞迁移抑制因子的功能及临床研究进展 [J]. 生理科学进展, 2014, (2): 93-99.
[9]	陈更越. HO-1及MIF在胎盘组织中的表达与子痫前期发病的相关性研究简 [J]. 解放军预防医学杂志, 2016, (S1): 2-3.
[10]	Valio-Rivas L, Baeza-Bermejillo C, Gonzalez-Lafuente L, et al. CD74 in kidney disease [J]. Front Immunol, 2015, 6: 483.
[11]	Loegl J, Hiden U, Nussbaumer E, et al. Hofbauer cells of M2a, M2b and M2c polarisation may regulate feto-placental angiogenesis [J]. 2016, 152(5): 447-455.
[12]	Tang Z, Abrahams VM, Mor G, Guller S. Placental Hofbauer cells and complications of pregnancy [J]. Ann N Y Acad Sci, 2011, 1221: 103-108.
[13]	Li M, Piao L, Chen C P, et al. Modulation of Decidual Macrophage Polarization by Macrophage Colony-Stimulating Factor Derived from First-Trimester Decidual Cells: Implication in Preeclampsia. [J]. American Journal of Pathology, 2016, 186(5): 1258-1266.
[14]	Nahar L, Nahar K, Hossain MI, et al. Placental changes in pregnancy induced hypertension [J]. Mymensingh Med J, 2015, 24(1): 9-17
[15]	谢晓芳，宋成凤. 子痫前期患者oxLDL、8-isoprostane、MDA和MIF的检测及意义 [J]. 南昌大学学报(医学版), 2016, 56(4): 26-29.
[16]	Harmon Ashlyn C, Cornelius Denise C, Amaral Lorena M, et al. The role of inflammation in the pathology of preeclampsia [J]. Clin Sci (Lond), 2016, 130(6): 409-419.
[17]	Cardaropoli S, Paulesu L, Romagnoli R, et al. Macrophage migration inhibitory factor in fetoplacental tissues from preeclamptic pregnancies with or without fetal growth restriction [J]. Clin Dev Immunol, 2012, 2012: 639342.
[18]	刘兴会，王晓东，何国琳. 子痫前期发病机制的研究现状及展望 [J]. 四川大学学报医学版, 2015, 46(1): 99-103.
[19]	Ji L, Brkić J, Liu M, et al. Placental trophoblast cell differentiation: Physiological regulation and pathological relevance to preeclampsia [J]. Mol Aspects Med, 2013, 34(5): 981-1023.
[20]	Morgan LZ, Rollins B, Sequeira A, et al. Quantitative trait locus and brain expression of HLA-DPA1 offers evidence of shared immune alterations in psychiatric disorders [J]. Microarrays(Basel), 2016, 5(1): 6.
[21]	Lockwood CJ, Matta P, Krikun G, et al. Regulation of monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha and interleukin-1beta in first trimester human decidual cells: implications for preeclampsia [J]. Am J Pathol, 2006, 168: 445-452.
[22]	Fest S, Aldo PB, Abrahams VM, et al. Trophoblast-macrophage interactions: a regulatory network for the protection of pregnancy [J]. Am J Reprod Immunol, 2007, 57: 55-66.
[23]	Faas MM, Spaans F, De Vos P. Monocytes and macrophages in pregnancy and pre-eclampsia [J]. Front Immunol, 2014, 5: 298.

Please choose a citation manager

Content to export