Clinical significance of expression of NFE2L3 gene in colorectal cancer: An analysis based on data-mining of Oncomine and GEPIA databases

doi:10.3877/cma.j.issn.1674-0785.2018.12.001

Abstract

Abstract:

Objective

To obtain the gene expression signatures of NFE2L3 and analyze its clinical significance by mining the data from Oncomine and GEPIA databases.

Methods

Differential NFE2L3 mRNA expression in colorectal cancer (CRC) was detected based on the Oncomine and GEPIA databases. Correlations between MTERF3 mRNA expression and mismatch repair genes, clinical stages and prognosis in CRC were analyzed by secondary analysis of the GEPIA database. Gene expression differences between cancer and normal tissues were analyzed by the t-test. One-way analysis of variance was used to compare gene expression between different clinical stages. Person correlation analysis was used for correlation study, and Kaplan-Meier method was used for survival analysis.

Results

A total of 334 different studies were collected in the Oncomine database, of which 55 showed statistically significant expression of NFE2L3. A total of 21 studies involved the expression of NFE2L3 in colorectal cancer tissues and normal tissues, including a total of 1000 samples. Compared with the control group, the expression of NFE2L3 mRNA in colorectal cancer tissues was significantly higher than that in normal colorectal tissues (P<0.05). In the GEPIA database, the expression of NFE2L3 gene was significantly correlated with the expression of mismatch repair genes MLH1, MSH2, MSH6 and PMS2 (P<0.05). However, there was no correlation between clinical stage and colorectal cancer survival (overall survival and disease-free survival) (P>0.05).

Conclusion

NFE2L3 mRNA is highly expressed in colorectal cancer tissues and is closely related to the expression of mismatch repair genes.

Key words: Human nuclear factor erythroid 2-related factor 3, Colorectal cancer, Oncomine, Gene expression profiling, interactive analysis

Chi Lyu, Yichao Liang, Zhaopeng Yan, Di Wu, Dalu Wang, Heling Wang, Qi Su, Hongzhuan Yin. Clinical significance of expression of NFE2L3 gene in colorectal cancer: An analysis based on data-mining of Oncomine and GEPIA databases[J]. Chinese Journal of Clinicians(Electronic Edition), 2018, 12(12): 651-658.

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Figures/Tables 7

References 23

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