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Chinese Journal of Clinicians(Electronic Edition) ›› 2019, Vol. 13 ›› Issue (07): 521-526. doi: 10.3877/cma.j.issn.1674-0785.2019.07.008

Special Issue:

• Clinical Research • Previous Articles     Next Articles

Effect of pulmonary rehabilitation on BODE index and serum inflammatory factors in patients with stable chronic obstructive pulmonary disease

Zhenglu Yin1, Zhaoxiang Meng1, Jibing Wang1, Bo Chen1, Shuangyue Yang1, Yifeng Quan1,()   

  1. 1. Department of Rehabilitation, Jiangsu Northern People′s Hospital, Yangzhou 225002, China
  • Received:2019-02-27 Online:2019-04-01 Published:2019-04-01
  • Contact: Yifeng Quan
  • About author:
    Corresponding author: Quan Yifeng, Email:

Abstract:

Objective

To observe the effect of pulmonary rehabilitation on BODE index and serum inflammatory factors in patients with moderate to severe chronic obstructive pulmonary disease (COPD).

Methods

From January 2016 to December 2017, 65 patients with stable COPD at our hospital were randomly divided into two groups: pulmonary rehabilitation group (n=33) and control group (n=32). Age, disease duration, BODE index and its individual components, serum high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor (TNF-α), and COPD quality of life score (Chinese version of the COPD-QOL scale) were measured. The relevant indicators were compared between before and after 12 weeks of treatment and between two groups by the paired sample t-test and independent sample t-test. Gender and clinical severity of COPD were compared using the χ2 test between groups.

Results

Sixty-three patients completed the study. The body mass index (BMI), modified dyspnea index (MMRC grade), and 6-minute walk test (6MWD) of the BODE index in the post-treatment group were improved compared with those before treatment [(21.5±1.4) kg/m2 vs (18.7±1.2) kg/m2; (1.6±0.3) vs (2.1±0.3); (270.3±37.8) m vs (158.3±42.4), t=2.125, 2.036, and 5.021, P=0.036, 0.046, and <0.001, respectively]. 6MWD in the control group was statistically significantly improved after treatment [(188.3±40.3) m vs (160.1±39.7) m, t=2.659, P=0.009]. The improvements of BMI, MMRC, and 6MWD in the lung rehabilitation group were significantly better than those in the control group [(21.5±1.4) kg/m2 vs (18.6±1.3) kg/m2, (1.6±0.3) vs (2.1±0.4), (270.3±37.8) m vs (188.3±40.3) m, t=2.124, 2.031, and 4.568, P=0.038, 0.016, and <0.001, respectively]. The BODE index was also significantly improved in the lung rehabilitation group than in the control group [(3.9±0.9) scores vs (4.5±1.3) scores, t=2.131, P=0.037]. After treatment, IL-6 and TNF-α in the lung rehabilitation group were significantly lower than those before treatment [(62.1±6.4) pg/ml vs (95.9±5.9) pg/ml; (48.5±7.3) pg/ml vs (73.3±10.1) pg/ml, t=7.872 and 7.136, P<0.001 for both], and the total score of COPD-QOL was significantly higher than that before treatment [(110.5±17.8) scores vs (96.2±20.4) scores, t=7.521, P<0.001). Compared with the control group, IL-6, TNF-α, and total COPD-QOL improved significantly in the lung rehabilitation group [(62.1±6.4) pg/ml vs (94.6±6.3) pg/ml, (48.5±7.3) pg/ml vs (71.7±7.5) pg/ml, (110.5±17.8) vs (96.3±21.3), t=7.981, 7.328, and 7.526, P<0.001 for all].

Conclusion

Pulmonary rehabilitation can significantly improve the BODE index, reduce serum IL-6 and TNF-α, and improve the quality of life in patients with moderate to severe COPD.

Key words: Pulmonary rehabilitation, Pulmonary disease, chronic obstructive, Stable stage, BODE index, Chemokines

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