Progress in clinical application of menstrual blood-derived stem cells

doi:10.3877/cma.j.issn.1674-0785.2020.05.013

Abstract

Abstract:

Menstrual blood stem-derived cells are mesenchymal stem cells derived from menstrual blood. They have the advantages of abundant source, non-invasive acquisition, easy isolation and culture, high proliferation rate, high number of passages, low immunogenicity, and no ethical controversy. In the treatment of various diseases, menstrual blood stem-derived cells show a good therapeutic potential and have broad clinical application prospects. However, there are still many problems to be solved before they become a clinical routine treatment.

Key words: Menstrual blood-derived stem cells, Biological characteristics, Stem cell transplantation, Regenerative medicine

Xianying Cheng, Jinhong Zhou. Progress in clinical application of menstrual blood-derived stem cells[J]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(05): 385-390.

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References 37

1	Meng X, Ichim TE, Zhong J, et al. Endometrial regenerative cells: A novel stem cell population [J]. J Transl Med, 2007, 5: 57-66.
2	Cui CH, Uyama T, Miyado K, et al. Menstrual blood-derived cells confer human dystrophin expression in the model of Duchenne muscular dystrophy via cell fusion and myogenic transdifferentiation [J]. Molecular Biology of the Cell, 2007, 18: 1586-1594.
3	Liu YL, Niu CR, Yang F, et al. Biological characteristics of human menstrual blood-derived endometrial stem cells [J]. J Cell Mol Med, 2018, 22(3): 1627-1639.
4	Lv h, Hu YL, Cui ZF, et al. Human menstrual blood: a renewable and sustainable source of stem cells for regenerative medicine stem cell [J].Research & Therapy, 2018, 9: 325.
5	Borlongan CV, Kaneko Y, Maki M, et al. Menstrual blood cells display stem cell-like phenotypic markers and exert neuroprotection following transplantation in experimental stroke [J]. Stem Cells Dev, 2010, 19: 439-452.
6	Nikoo S, Ebtekar M, Jeddi-Tehrani M, et al. Menstrual blood-derived stromal stem cells from women with and without endometriosis reveal different phenotypic and functional characteristics [J]. Mol Hum Reprod, 2014, 20: 905-918.
7	Chen LJ, Qu JJ, Xian CL. The multi-functional roles of menstrual blood-derived stem cells in regenerative medicine Stem [J]. Cell Research & Therapy, 2019, 10: 1.
8	Wu X, Luo Y, Chen J, et al. Transplantation of human menstrual blood progenitor cells improves hyperglycemia by promoting endogenous progenitor differentiation in type 1 diabetic mice [J]. Stem Cells Dev, 2014, 23: 1245-1257.
9	Chen J, Du X, Chen Q, et al. Effects of donors′age and passage number on the biological characteristics of menstrual blood-derived stem cells [J]. Int J Clin Exp Pathol, 2015, 8(11): 14584-14595.
10	Liu T, Huang Y, Zhang J, et al. Transplantation of human menstrual blood stem cells to treat premature ovarian failure in mouse model [J]. Stem Cells and Development, 2014, 23: 1548-1557.
11	Hida N, Nishiyama N, Miyoshi S, et al. Novel cardiac precursor-like cells from human menstrual blood-derived mesenchymal cells [J]. Stem Cells, 2008, 26: 1695-1704.
12	Zheng SX, Wang J, Wang XL, et al. Feasibility analysis of treating severe intrauterine adhesions by transplanting menstrual blood-derived stem cells [J]. Int J Mol Med, 2018, 41(4): 2201-2212.
13	Lai D, Guo Y, Zhang Q, et al. Differentiation of human menstrual blood-derived endometrial mesenchymal stem cells into oocyte-like cells [J]. Acta Biochim Biophys Sin, 2016, 48: 998-1005.
14	Chen L, Zhang C, Chen L, et al. Human menstrual blood-derived stem cells ameliorate liver fibrosis in mice by targeting hepatic stellate cells via paracrine mediators [J]. Stem Cells Transl Med, 2017, 6: 272-684.
15	Wang F, Yao X, Zhao Y, et al. Human endometrial mesenchymal stem cells restore ovarian function through improving the renewal of germline stem cells in a mouse model of premature ovarian failure [J]. J Transl Med, 2015, 13: 155.
16	Masuda H, Anwar SS, Bühring HJ, et al. A novel marker of human endometrial mesenchymal stem-like cells [J]. Cell Transpl, 2012, 21(10): 2201-2214.
17	Peron JPS, Jazedje T, Brandao WN, et al. Human endometrial-derived mesenchymal stem cells suppress inflammation in the central nervous system of EAE mice [J]. Stem Cell Rev Rep, 2012, 8(3): 940-952.
18	Bozorgmehr M, Moazzeni SM, Salehnia M, et al. Menstrual blood-derived stromal stem cells inhibit optimal generation and maturation of human monocyte-derived dendritic cells [J]. Immunol Lett, 2014, 162: 239-246.
19	Murphy MP, Wang H, Patel AN, et al. Allogeneic endometrial regenerative cells: an "Off the shelf solution" for critical limb ischemia? [J]. J Trans Med, 2008, 6: 45.
20	Jiang Z, Hu X, Yu H, et al. Human endometrial stem cells confer enhanced myocardial salvage and regeneration by paracrine mechanisms [J]. J Cell Mol Med, 2013, 17(10): 1247-1260.
21	Zhang Z, Wang JA, Xu Y, et al. Menstrual blood derived mesenchymal mesenchymal cells ameliorate cardiac fibrosis via inhibition of endothelial to transition in myocardial infarction [J]. Intern J Cardiol, 2013, 168: 1711-1714.
22	Wang K, Jiang Z, Webster KA, et al. Enhanced cardioprotection by human endometrium mesenchymal stem cells driven by exosomal MicroRNA-21 [J]. Stem Cells Transl Med, 2017, 6: 209-222.
23	Ichim TE, Solano F, Lara F, et al. Combination stem cell therapy for heart failure [J]. Int Arch Med, 2010, 3: 5.
24	Lan X, Wang G, Xu X, et al. Stromal cell-derived factor-1 mediates cardiac allograft tolerance induced by human endometrial regenerative cell-based therapy [J]. Stem Cells Transl Med, 2017, 6(11): 1997-2008.
25	Xiang B, Chen L, Wang X, et al. Transplantation of menstrual blood-derived mesenchymal stem cells promotes the repair of LPS-induced acute lunginjury [J]. Int J Mol Sci, 2017, 18: 689.
26	Chen L, Xiang B, Wang X, et al. Exosomes derived from human menstrual blood-derived stem cells alleviate fulminant hepatic failure [J]. Stem Cell Res Ther, 2017, 8: 9.
27	Zhao Y, Chen X, Wu Y, et al. Transplantation of human menstrual blood-derived mesenchymal stem cells alleviates Alzheimer′s disease-like pathology in APP/PS1 transgenic mice [J]. Front Mol Neurosci, 2018, 11: 140.
28	Ichim TE, Alexandrescu DT, Solano F, et al. Mesenchymal stem cells as anti-inflammatories: implications for treatment of Duchenne muscular dystrophy [J]. Cell Immunol, 2010, 260(2): 75-82.
29	Lai D, Wang F, Yao X, et al. Human endometrial mesenchymal stem cells restore ovarian function through improving the renewal of germline stem cells in a mouse model of premature ovarian failure [J]. J Transl Med, 2015, 13: 155.
30	Wang Z, Wang Y, Yang T, et al. Study of the reparative effects of menstrual-derived stem cells on premature ovarian failure in mice [J]. Stem Cell Res Ther, 2017, 8: 11.
31	Hu J, Song KY, hang J, et al. Effects of menstrual blood derived stem cells on endometrial injury repair [J]. Molecular Medicine Reports, 2018, 19(2): 813-820.
32	Zhang Y, Lin X, Dai Y, et al. Endometrial stem cells repair injured endometrium and induce angiogenesis via AKT and ERK pathways [J]. Reproduction, 2016, 152: 389-402.
33	Zhu HY, Jiang YS, Pan YB, et al.Human menstrual blood-derived stem cells promote the repair of impaired endometrial stromal cells by activating the p38 MAPK and AKT signaling pathways [J].Reproductive Biology, 2018, 18: 274-281.
34	Tan J, Li P, Wang Q, et al. Autologous menstrual blood-derived stromal cells transplantation for severe Asherman′s syndrome [J]. Hum Reprod, 2016, 31: 2723-2729.
35	Ulrich D, Edwards SL, Su K, et al. Human endometrial mesenchymal stem cells modulate the tissue response and mechanical behavior of polyamide mesh implants for pelvic organ prolapse repair [J]. Tissue Eng Part A, 2014, 20: 785-798.
36	Cuenca J, Le-Gatt A, Castillo V, et al. The reparative abilities of menstrual stem cells modulate the wound matrix signals and improve cutaneous regeneration [J]. Front Physiol, 2018, 9: 464.
37	Wang XJ, Xiang BY, Ding YH, et al. Human menstrual blood-derived mesenchymal stem cells as a cellular vehicle for malignant glioma gene therapy [J]. Oncotarget, 2017, 8: 58309-58321.

来源	胚胎	体细胞	骨髓	脂肪	脐带	月经血
丰富程度	?	＋	?	＋	?	＋
伦理问题	＋	?	?	?	?	?
免疫原性	＋	＋	?	?	?	?
无创性	?	＋	?	?	＋	＋
免疫调节	?	?	＋	＋	＋	＋
自体获取	?	＋	＋	＋	?	＋
致瘤性	＋	＋	?	?	?	?

来源	胚胎	体细胞	骨髓	脂肪	脐带	月经血
丰富程度	?	＋	?	＋	?	＋
伦理问题	＋	?	?	?	?	?
免疫原性	＋	＋	?	?	?	?
无创性	?	＋	?	?	＋	＋
免疫调节	?	?	＋	＋	＋	＋
自体获取	?	＋	＋	＋	?	＋
致瘤性	＋	＋	?	?	?	?

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