Application of adeno-associated virus in Parkinson′s disease

doi:10.3877/cma.j.issn.1674-0785.2020.08.012

Abstract

Abstract:

Parkinson′s disease is a degenerative disease of the central nervous system that is common in middle-aged and elderly people, and its pathogenesis is still largely unclear. Current treatment strategies are aimed at reducing symptoms and slowing the progression of the disease. The applications of adeno-associated virus-mediated gene delivery include neurobiological research, disease modelling, and gene therapy. Adeno-associated virus as a neurotracer can be used to explore the basal ganglia circuit, providing an important tool for the research of the pathogenesis of Parkinson′s disease. The use of therapeutic genes carried by adeno-associated virus vectors has brought broad therapeutic prospects to Parkinson′s disease. In recent years, animal experiments and clinical studies of adeno-associated viruses for Parkinson′s disease have been carried out both in China and other countires, and some progress has been made. How to make better use of adeno-associated viruses and minimize the adverse reactions will become a hot research topic in the future.

Key words: Adeno-associated virus, Parkinson′s disease, Basal ganglia loop, Nerve tracer, Gene therapy

Tianqi He, Xiaotao Zhang, Min Wang, Xiuhua Li. Application of adeno-associated virus in Parkinson′s disease[J]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(08): 643-647.

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