To explore the effects of alprostadil injection on the recovery of nerve function, blood rheology, and serum inflammatory factors in patients with ischemic stroke.

From March 2018 to May 2019, 100 patients with ischemic stroke admitted to Shenzhen Second People's Hospital were selected, and the patients were divided into either an observation group (n=50) or a control group (n=50) using a random number table. Both groups received conventional neurology treatment, and the observation group was additionally treated with alprostadil injection. The changes in nerve function, blood rheology, and serum inflammatory factor levels of the two groups before and after treatment were compared and analyzed.

Before treatment, there was no significant difference in baseline information between the two groups (P＞0.05). The total effective rate in the observation group was significantly higher than that of the control group (96% vs 78%, P＜0.05). Compared with the values before treatment, neurological function, blood rheology, serum inflammatory factors, and other indicators were significantly improved after treatment in both groups (P＜0.05). After treatment, NIHSS score [(13.43±4.08) vs (19.67±4.06), P＜0.05], MoCA score [(28.75±2.76) vs (26.06±2.64), P＜0.05], and ADL score [(90.26±5.27) vs (76.16±5.82), P<0.05] differed significantly between the observation group and control group; FIB [(2.07±0.32) g/L vs (3.35±0.41) g/L], PV [(2.04±0.65) mPa.s vs (3.56±0.70) mPa.s], LBV [(15.06±3.42) mPa.s vs (18.44±3.18) mPa.s], and ERI [(2.42±0.11) vs (3.47±0.24)] were significantly lower in the observation group than in the control group (P＜0.05); serum HMG-B1 [(4.54±1.12) μg/ml vs (8.65±1.67) μg/ml], IL-8 [(64.62±11.54) pg/ml vs (88.64±9.17) pg/ml], and TNF-α [(36.17±4.67) mmol/L vs (59.45±4.09) mmol /L] were also significantly lower in the observation group than in the control group (P＜0.05).

Alprostadil injection can effectively improve hemorheology, inhibit the release of serum inflammatory factors, reduce the degree of brain injury, promote neurological function recovery, and improve prognosis in patients with ischemic stroke.