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Chinese Journal of Clinicians(Electronic Edition) ›› 2020, Vol. 14 ›› Issue (11): 931-936. doi: 10.3877/cma.j.issn.1674-0785.2020.11.016

Special Issue:

• Review • Previous Articles     Next Articles

Advances in research of TGFBI-related granular corneal dystrophy

Haoliang Li1, Shu Liang1,()   

  1. 1. Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
  • Received:2020-05-21 Online:2020-11-15 Published:2021-03-23
  • Contact: Shu Liang

Abstract:

Granular corneal dystrophy (GCD) is a group of autosomal dominant genetic diseases and belongs to a more common category of corneal dystrophy. Studies have confirmed that mutations in the TGFBI gene can cause GCD. Mutations at different sites in the TGFBI gene can lead to different types of GCD. By reviewing the relevant literature, we summarize TGFBI-related GCD with regard to its pathogenic genes, typing and clinical manifestations, pathogenesis, and treatment.

Key words: TGFBI gene, Granular corneal dystrophy, Gene mutation

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