Role of platelets and their surface receptors and ligands in septic coagulopathy

doi:10.3877/cma.j.issn.1674-0785.2021.04.012

Abstract

Abstract:

Platelets are small anuclear cells that have a critical role in hemostasis. Recent studies have found that platelets play an important role in inflammation and immune response. In sepsis, multiple factors stimulate platelet activation, especially the lipopolysaccharide, which promotes platelet activation and enhances platelet aggregation by stimulating platelet secretion. The activated platelets express a variety of receptors, among which P-selectin plays an initiating role in the inflammatory response. Moreover, GP Ⅱb/Ⅲa activation and binding to fibrinogen is a common pathway and essential step for platelet aggregation caused by various causes. Both P-selectin and GP Ⅱb/Ⅲa play a vital role in septic coagulopathy. Activated platelets interact with leukocytes and endothelial cells, catalyzing excessive inflammatory response and coagulation dysfunction, leading to disseminated intravascular coagulation and microcirculatory thrombosis, and eventually causing multiple organ failure. In addition, activated platelets shed platelet products, known as platelet-derived microparticles, which enhance inflammation and coagulation. This paper reviews the research progress in the understanding of the role of platelets and their surface receptors and ligands in septic coagulopathy.

Key words: Sepsis, Platelet, Inflammatory response, Immunomodulatory

Min Mao, Xiu Li, Zidan Wang, Liang Shan. Role of platelets and their surface receptors and ligands in septic coagulopathy[J]. Chinese Journal of Clinicians(Electronic Edition), 2021, 15(04): 302-307.

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