Advances in understanding of brain protective mechanisms of n-3 polyunsaturated fatty acids

doi:10.3877/cma.j.issn.1674-0785.2023.04.018

Abstract

Abstract:

n-3 polyunsaturated fatty acids (PUFAs) play a variety of roles in brain development and the treatment of neurological diseases, including neonatal brain injury, autism spectrum disorder, Alzheimer's disease, schizophrenia, etc. The mechanisms underlying the protective effect of n-3 PUFAs on the brain have always been a research hotspot. The possible mechanisms include regulating synaptic plasticity and membrane receptor function, modulating signal transduction pathways, anti-inflammatory properties, and producing lipid mediators. This review reviews the progress in the understanding of the brain protective mechanisms of n-3 PUFAs, so as to help identify therapeutic targets for the relevant diseases and promote clinical translation.

Key words: n-3 polyunsaturated fatty acids, Brain, Mechanism, Therapy

Qiuyue Shen, Xinlin Hou. Advances in understanding of brain protective mechanisms of n-3 polyunsaturated fatty acids[J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(04): 471-478.

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