To investigate the correlation of clinical risk factors in pulmonary hypertension patients with different levels of tricuspid regurgitation velocity.

Inpatients admitted to the Department of Cardiology of the Affiliated Hospital of Yangzhou University in 2021 were selected. The results of cardiac color ultrasound indicated that 101 patients with pulmonary hypertension had a tricuspid regurgitation velocity >280 cm/s (TV>280 cm/s), and they were divided into a low TV group (TV<300 cm/s) and a high TV group (TV>300 cm/s) according to the tricuspid regurgitation velocity. The clinical characteristics, routine blood parameters, renal function, and lipid panel were compared between the two groups. The risk factors for pulmonary hypertension and the correlation of pulmonary hypertension with tricuspid regurgitation velocity at different levels were analyzed by Logistic binary regression. The predictive value and efficacy of left atrium and right ventricle size were evaluated by receiver operating characteristic (ROC) curve analysis.

The prevalence of heart failure in the high TV group was significantly higher than that of the low TV group. The levels of high-density lipoprotein (HDL) and apolipoprotein A in the low TV group were significantly higher than those of the high TV group (P<0.05). The mean diameter of the left atrium and right ventricle in the low TV group was significantly lower than that of the high TV group (P<0.05). TV was positively correlated with the diameter of the left atrium and right ventricle (P<0.01), and negatively correlated with the levels of HDL and apolipoprotein A (P<0.05). Logistic binary regression analysis showed that heart failure, left atrial enlargement, and right ventricular enlargement (P<0.05) were independent risk factors for pulmonary hypertension, and elevated apolipoprotein A level (P<0.05) was a protective factor for pulmonary hypertension. ROC curve analysis showed that the area under the ROC curve (AUC) of left atrial diameter for predicting pulmonary hypertension was 0.640 (P<0.05), with a sensitivity of 47.1% and specificity of 79.6%. The AUC of right ventricular diameter in predicting pulmonary hypertension was 0.643 (P<0.05), with a sensitivity of 56.9% and specificity of 69.4%. The AUC of combined prediction by left atrial diameter plus right ventricular diameter was 0.643 (P<0.05), with a specificity of 83.7%.

The greater the tricuspid valve regurgitation velocity in patients with pulmonary hypertension, the more likely it is to lead to cardiac structural changes, often resulting in enlargement of the left atrium and right ventricle. In clinical diagnosis and treatment, attention paid to tricuspid valve regurgitation velocity, early detection of ventricular remodeling, and early intervention can improve the prognosis of patients with pulmonary hypertension.