To evaluate the efficacy of letrozole combined with metformin and dydrogesterone in the treatment of polycystic ovarian syndrome (PCOS) with infertility.

A total of 230 patients with PCOS complicated with infertility who visited the obstetrics and gynecology clinic of Affiliated Hospital of Beihua University were randomly divided into a control group (n=115) and an observation group (n=115). Patients in the control group were treated with letrazole alone, and those in the observation group were treated with letrazole combined with metformin and dydrogesterone. Ultrasound was used to confirm the follicle diameter in the two groups, blood tests were performed to determine the levels of serum estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T), and the therapeutic effect was assessed.

At different time points, the follicle diameter of patients in the observation group significantly increased compared to that of the control group (P<0.01). The changes in serum E2, FSH, T, and LH levels were statistically significant in both groups of patients (P<0.01). The total effective rate in the control group was 86.96%, which was signifciantly lower than that of the observation group (93.91%; P<0.05).

Letrozole combined with metformin and dydrogesterone has more significant therapeutic effect on PCOS with infertility than letrozole alone. The combination therapy can effectively improve the follicle diameter, correct serum endocrine hormone indicators, and promote the possibility of pregnancy.