Abstract:

Objective

To investigate the clinical manifestations, diagnosis, pathological features,treatment and prognosis of retroperitoneal synovial sarcoma, and to improve surgeons' understanding of retroperitoneal synovial sarcoma.

Methods

Retrospective analysis was made on the clinical data of 7 cases of retroperitioneal synovial sarcoma patients undergoing surgical resection in Peking University International Hospital from January 2015 to January 2024,and to do the follow-up visit.

Results

The clinical manifestations of the patients were not typical, most of them were low back pain (2 cases) and abdominal pain (4 cases).The characteristic findings of CT were that the tumor was lobed or lumpy soft tissue mass,the density was slightly lower than the muscle density, and necrosis area was visible in the tumor body.The enhanced scan showed uniform or uneven enhancement, and sometimes calcification was seen at the edge of the mass.All patients in this group underwent surgical treatment, and the tumors were often larger and invaded the surrounding organs.Postoperative complications occurred in 2 cases (gastroparesis 1, intestinal basket 1),and perioperative death occurred in 1 case (respiratory failure).SS18 gene rearrangement was present in all 7 patients.All patients were followed up until March 2024 and died of the disease,median survival was 56 months.

Conclusion

The clinical manifestations of patients with synovial sarcoma are nonspecific, and the characteristic chromosomal translocation is the gold standard for diagnosis.Surgical resection is still the main treatment.This kind of tumor has high malignant degree, easy recurrence after operation and poor prognosis.

Key words: Synovial sarcoma, Diagnosis, Surgical procedures