Progress in understanding the role of tumor-associated macrophages in hepatocellular carcinoma angiogenesis

doi:10.3877/cma.j.issn.1674-0785.2025.05.009

Abstract

Abstract:

Tumor-associated macrophages (TAMs) are essential components of the hepatocellular carcinoma (HCC) tumor microenvironment (TME) and participate in processes such as tumor cell proliferation, invasive migration, angiogenesis, and progression of liver fibrosis in HCC. TAMs can regulate angiogenesis in HCC by secreting pro-angiogenic factors, interacting with endothelial cells, and increasing vascular permeability. This article reviews the role of TAMs in angiogenesis of HCC, aiming to identify potential targets for inhibiting tumor angiogenesis by targeting TAMs.

Key words: Tumor-associated macrophages, Hepatocellular carcinoma, Angiogenesis, Tumor microenviroment

Shilun Wu, Changyu Yao, Li Xu, Zhishan Di, Qi Xia, Wenbing Sun, Jian Kong. Progress in understanding the role of tumor-associated macrophages in hepatocellular carcinoma angiogenesis[J]. Chinese Journal of Clinicians(Electronic Edition), 2025, 19(05): 388-391.

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https://zhlcyszz.cma-cmc.com.cn/EN/Y2025/V19/I05/388

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