From mechanisms to therapeutics: The role of macrophages in diabetic nephropathy

doi:10.3877/cma.j.issn.1674-0785.2025.07.010

Abstract

Abstract:

Diabetic nephropathy is becoming the main cause of chronic kidney disease. Although more and more evidence indicates that immunity and inflammation are highly involved in the pathogenesis and progression of diabetic nephropathy, the underlying mechanisms remain unclear. This review mainly summarizes the phenotypic changes of macrophages, focuses on the interaction between macrophages and intrinsic renal cells, further explores the mechanism of macrophages in the occurrence and development of diabetic nephropathy, and provides new ideas for the development of treatment methods and drugs for diabetic nephropathy.

Key words: Diabetic nephropathy, Macrophages, Renal cells

Zhiqi Zhao, Xiaoli Wu, Ruoqi Liu, Zhuomin Qu, Dongran Li, Lingxia Zhao. From mechanisms to therapeutics: The role of macrophages in diabetic nephropathy[J]. Chinese Journal of Clinicians(Electronic Edition), 2025, 19(07): 544-549.

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