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中华临床医师杂志(电子版) ›› 2018, Vol. 12 ›› Issue (05) : 297 -301. doi: 10.3877/cma.j.issn.1674-0785.2018.05.008

所属专题: 文献

综述

白藜芦醇对脓毒症诱导机体损伤的保护作用及机制研究进展
周佳伟1, 刘凯1, 侯林义1, 张文凯1,()   
  1. 1. 030001 太原,山西医科大学第二医院重症医学科
  • 收稿日期:2017-12-29 出版日期:2018-03-01
  • 通信作者: 张文凯
  • 基金资助:
    山西省回国留学人员科研资助项目(2011-105); 山西省太原市科技项目(12016905)

Protective effect and mechanism of resveratrol in sepsis induced body injury

Jiawei Zhou1, Kai Liu1, Linyi Hou1, Wenkai Zhang1,()   

  1. 1. Intensive Care Unit, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2017-12-29 Published:2018-03-01
  • Corresponding author: Wenkai Zhang
  • About author:
    Corresponding author: Zhang Wenkai, Email:
引用本文:

周佳伟, 刘凯, 侯林义, 张文凯. 白藜芦醇对脓毒症诱导机体损伤的保护作用及机制研究进展[J]. 中华临床医师杂志(电子版), 2018, 12(05): 297-301.

Jiawei Zhou, Kai Liu, Linyi Hou, Wenkai Zhang. Protective effect and mechanism of resveratrol in sepsis induced body injury[J]. Chinese Journal of Clinicians(Electronic Edition), 2018, 12(05): 297-301.

脓毒症是严重的全身化脓性感染,可引起休克、多器官功能障碍,具有高发病率、高病死率、高治疗费用的三高特点,而且其发病率每年还在以1.5%~1.8%的速度增长。脓毒症可以直接导致患者多脏器功能衰竭,是引起重症患者死亡的主要原因之一。虽然人们对脓毒症发病机制的认识越来越深,但是目前的治疗措施,如抗炎、抗氧化、抗血小板聚集和抗微循环衰竭等,仍然未能明显减低患者死亡的风险。目前,研究者发现植物的提取及合成试剂白藜芦醇具有明显的抗炎、抗氧化作用,可以改善脓毒症引起的机体损伤状况,提高生存率,但是其具体作用机制未能完全明确。本综述总结了白藜芦醇在脓毒症导致的机体损伤中的保护作用机制,为今后脓毒症治疗的研究方向提供新的理论。

Sepsis is a type of severe systemic suppurative infection that can cause shock and dysfunction of multiple organs. It possesses the characteristics of high morbidity, high mortality, and high treatment cost. Sepsis can directly lead to multiple organ failure, which is one of the main causes of death of severe patients. Although researchers have had a deeper understanding of the pathogenesis of sepsis, the current treatment measures, such as anti-inflammation, anti-oxidation, anti-platelet aggregation, and anti-microcirculation failure, have not significantly reduced the risk of death. At present, researchers have found that plant extraction and synthetic reagent resveratrol has obvious anti-inflammatory and antioxidant effects and can improve sepsis induced body injury and increase survival rate; however, the exact mechanism of action is not completely clear. This review summarizes the protective effect and mechanism of resveratrol in sepsis induced body injury, with an aim to provide new clues to the treatment of sepsis.

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