切换至 "中华医学电子期刊资源库"

中华临床医师杂志(电子版) ›› 2021, Vol. 15 ›› Issue (05) : 393 -396. doi: 10.3877/cma.j.issn.1674-0785.2021.05.015

综述

维生素D对多囊卵巢综合征患者生育影响的研究进展
王研1, 丁旭2, 黄艳红3,()   
  1. 1. 710032 西安,空军军医大学第一附属医院妇产科
    2. 710100 西安,西安国际医学中心医院生殖内分泌科
    3. 710032 西安,空军军医大学第一附属医院妇产科;710100 西安,西安国际医学中心医院生殖内分泌科
  • 收稿日期:2020-11-06 出版日期:2021-05-15
  • 通信作者: 黄艳红
  • 基金资助:
    陕西省重点产业创新链-社会发展领域(2020ZDLSF03-01)

Effect of vitamin D on patients with polycystic ovary syndrome

Yan Wang1, Xu Ding2, Yanhong Huang3,()   

  1. 1. Department of Obstetrics and Gynecology, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China
    2. Department of Reproductive Endocrinology, Xi'an International Medical Center Hospital, Xi'an 710100, China
    3. Department of Obstetrics and Gynecology, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China; Department of Reproductive Endocrinology, Xi'an International Medical Center Hospital, Xi'an 710100, China
  • Received:2020-11-06 Published:2021-05-15
  • Corresponding author: Yanhong Huang
引用本文:

王研, 丁旭, 黄艳红. 维生素D对多囊卵巢综合征患者生育影响的研究进展[J]. 中华临床医师杂志(电子版), 2021, 15(05): 393-396.

Yan Wang, Xu Ding, Yanhong Huang. Effect of vitamin D on patients with polycystic ovary syndrome[J]. Chinese Journal of Clinicians(Electronic Edition), 2021, 15(05): 393-396.

多囊卵巢综合征(PCOS)是常见的妇科内分泌疾病,常见临床表现包括月经不规律、高雄激素血症、胰岛素抵抗及排卵障碍性不孕等。目前关于PCOS的确切病因与发病机制尚不清楚。研究发现PCOS患者普遍存在维生素D的缺乏,适当补充维生素D可能有助于改善PCOS患者的临床相关症状及生育情况。本文就目前维生素D对PCOS患者影响的相关文献进行综述。

Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disorder, with clinical manifestations of irregular menses, hyperandrogenaemia or excess levels of androgen, insulin resistance, anovulatory infertility, etc. At present, the exact etiology and pathogenesis of PCOS is still unclear. Studies have found that vitamin D deficiency is common in PCOS, and appropriate vitamin D supplementation may help improve clinically relevant symptoms and fertility status in patients with PCOS. This article reviews the current literature on the influence of vitamin D on PCOS patients.

1
Krul-Poel YHM, Koenders PP, Steegers-Theunissen RP, et al. Vitamin D and metabolic disturbances in polycystic ovary syndrome (PCOS): A cross-sectional study [J]. PloS One, 2018, 13(12): e0204748.
2
Costello MF, Misso ML, Balen A, et al. Evidence summaries and recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome: assessment and treatment of infertility [J]. Hum Reprod Open, 2019, 2019(1): hoy021.
3
Li R, Zhang Q, Yang D, et al. Prevalence of polycystic ovary syndrome in women in China: a large community-based study [J]. Hum Reprod, 2013, 28(9): 2562-2569.
4
Irani M, Merhi Z. Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review [J]. Fertility and Sterility, 2014, 102(2): 460-468. e3.
5
Zhao JF, Li BX, Zhang Q. Vitamin D improves levels of hormonal, oxidative stress and inflammatory parameters in polycystic ovary syndrome: a meta-analysis study [J]. Ann Palliat Med, 2021, 10(1): 169-183.
6
He C, Lin Z, Robb S, et al. Serum vitamin D levels and polycystic ovary syndrome: a systematic review and Meta-analysis [J]. Nutrients, 2015, 7(6): 4555-4577.
7
Thomson RL, Spedding S, Buckley JD. Vitamin D in the aetiology and management of polycystic ovary syndrome [J]. Clin Endocrinol (Oxf), 2012, 77(3): 343-350.
8
Joham AE, Teede HJ, Cassar S, et al. Vitamin D in polycystic ovary syndrome: relationship to obesity and insulin resistance [J]. Mol Nutr Food Res, 2016, 60(1): 110-118.
9
Arabian S, Raoofi Z. Effect of serum vitamin D level on endometrial thickness and parameters of follicle growth in infertile women undergoing induction of ovulation [J]. J Obstet Gynaecol, 2018, 38(6): 833-835.
10
Herian M, Luck MR, Grzesiak M. The influence of testosterone on the expression and function of vitamin D3 receptor (VDR) protein in the porcine ovarian follicle [J]. Physiol Res, 2018, 67(3): 515-519.
11
Krishnan AV, Moreno J, Nonn L, et al. Novel pathways that contribute to the anti-proliferative and chemopreventive activities of calcitriol in prostate cancer [J]. J Steroid Biochem Mol Biol, 2007, 103(3-5): 694-702.
12
Wojtusik J, Johnson PA. Vitamin D regulates anti-Mullerian hormone expression in granulosa cells of the hen [J]. Biol Reprod, 2012, 86(3): 91.
13
Butler AE, Ramachandran V, Hayat S, et al. Expression of microRNA in follicular fluid in women with and without PCOS [J]. Sci Rep, 2019, 9(1): 16306.
14
Walters KA, Handelsman DJ. Role of androgens in the ovary [J]. Mol Cell Endocrinol, 2018, 465: 36-47.
15
Al-Bayyari N, Al-Domi H, Zayed F, et al. Androgens and hirsutism score of overweight women with polycystic ovary syndrome improved after vitamin D treatment: a randomized placebo controlled clinical trial [J]. Clin Nutr, 2021, 40(3): 870-878.
16
Elenis E, Desroziers E, Persson S, et al. Early initiation of anti-androgen treatment is associated with increased probability of spontaneous conception leading to childbirth in women with polycystic ovary syndrome: a population-based multiregistry cohort study in Sweden [J]. Hum Reprod, 2021, 36(5): 1427-1435.
17
Sirmans SM, Pate KA. Epidemiology, diagnosis, and management of polycystic ovary syndrome [J]. Clin Epidemiol, 2013, 6: 1-13.
18
Kokanalı D, Karaca M, Ozakşit G, et al. Serum vitamin D levels in fertile and infertile women with polycystic ovary syndrome [J]. Geburtshilfe Frauenheilkd, 2019, 79(5): 510-516.
19
Neelankal John A, Jiang FX. An overview of type 2 diabetes and importance of vitamin D3-vitamin D receptor interaction in pancreatic β-cells [J]. J Diabetes Complications, 2018, 32(4):429-443.
20
Alvarez JA, Ashraf A. Role of vitamin D in insulin secretion and insulin sensitivity for glucose homeostasis [J]. Int J Endocrinol, 2010, 2010: 351385.
21
Javed Z, Papageorgiou M, Deshmukh H, et al. A randomized, controlled trial of vitamin D supplementation on cardiovascular risk factors, hormones, and liver markers in women with polycystic ovary syndrome [J]. Nutrients, 2019, 11(1): 188.
22
Miao CY, Fang XJ, Chen Y, et al. Effect of vitamin D supplementation on polycystic ovary syndrome: a meta-analysis [J]. Exp Ther Med, 2020, 19(4): 2641-2649.
23
Trummer C, Schwetz V, Kollmann M, et al. Effects of vitamin D supplementation on metabolic and endocrine parameters in PCOS: a randomized-controlled trial [J]. Eur J Nutr, 2019, 58(5): 2019-2028.
24
Zhao J, Liu S, Wang Y, et al. Vitamin D improves in-vitro fertilization outcomes in infertile women with polycystic ovary syndrome and insulin resistance [J]. Minerva Med, 2019, 110(3): 199-208.
25
Moran L, Brinkworth G, Norman R. Dietary therapy in polycystic ovary syndrome [J]. Semin Reprod Med, 2008, 26(1): 85-92.
26
Curvello-Silva KL, Oliveira NA, Silva TSS, et al. Association between cardiovascular risk factors and 25(OH)D levels in obese patients [J]. Metab Syndr Relat Disord, 2020, 18(7): 328-332.
27
Luo J, Li T, Yuan J. Effectiveness of vitamin D supplementation on lipid profile in polycystic ovary syndrome women: a meta-analysis of randomized controlled trials [J]. Ann Palliat Med, 2021, 10(1): 114-129.
28
Weeg N, Hershko Klement A, Haikin E, et al. The effect of maternal body mass index (BMI) and telomere function on in vitro fertilization (IVF) outcome: a preliminary cohort study [J]. Hum Fertil (Camb), 2020, 23(4): 282-288.
29
Marino R, Misra M. Extra-skeletal effects of vitamin D [J]. Nutrients, 2019, 11(7): 1460.
30
Hamid El Bilbeisi A, Shab-Bidar S, Jackson D, et al. The prevalence of metabolic syndrome and its related factors among adults in Palestine: a meta-analysis [J]. Ethiop J Health Sci, 2017, 27(1): 77.
31
Priyanka P, Anita K. Interplay of vitamin D and metabolic syndrome: a review [J]. Diabetes Metab Syndr, 2016, 10(2): 105-112.
32
Mogili KD, Karuppusami R, Thomas S, et al. Prevalence of vitamin D deficiency in infertile women with polycystic ovarian syndrome and its association with metabolic syndrome-A prospective observational study [J]. Eur J Obstet Gynecol Reprod Biol, 2018, 229: 15-19.
33
He Y, Lu Y, Zhu Q, et al. Influence of metabolic syndrome on female fertility and in vitro fertilization outcomes in PCOS women [J]. Am J Obstet Gynecol, 2019, 221(2): 138.e1-138.e12.
[1] 庄蕙嘉, 岳志成, 钟坤岑, 朱慧莉. 乳腺癌患者生育力保存的研究进展[J]. 中华乳腺病杂志(电子版), 2023, 17(04): 238-242.
[2] 居晓庆, 金蕴洁, 王晓燕. 剖宫产术后瘢痕子宫患者再次妊娠阴道分娩发生子宫破裂的影响因素分析[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 575-581.
[3] 周东杰, 蒋敏, 范海瑞, 高玲玲, 孔祥, 卢丹, 王丽萍. 非编码RNA在卵泡发育成熟中作用及其机制的研究现状[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(04): 387-393.
[4] 李聪, 徐艳, 吴铭, 丁瑞东, 王军. 极低出生体重儿出生时血清25-羟维生素D水平与其生后早期喂养不耐受关系的临床分析[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(03): 309-314.
[5] 李婷, 张琳. 血清脂肪酸代谢物及维生素D水平与结直肠癌发生的关系研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 661-665.
[6] 李晓晖, 上官昌盛, 向英, 裴芝皆, 车俊志, 谢飞. 3D腹腔镜袖状胃切除术后机体能量代谢与多囊卵巢综合征患者性激素水平关系[J]. 中华普外科手术学杂志(电子版), 2023, 17(05): 538-541.
[7] 方道成, 胡媛媛. 钙和维生素D与肾结石形成关系的研究进展[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(06): 653-656.
[8] 宋昕, 耿涛, 刘长春. 老年下呼吸道感染者血清25-羟维生素D3水平与血清炎症因子水平的关系[J]. 中华肺部疾病杂志(电子版), 2023, 16(02): 215-217.
[9] 符莞孟, 王晓黎, 刘玉, 张潍, 张菊. 干细胞治疗多囊卵巢综合征的研究进展[J]. 中华细胞与干细胞杂志(电子版), 2023, 13(02): 108-114.
[10] 吴文诗, 魏宋荃, 李桂民, 郑晓芳, 孙雯, 陈敦金, 余琳. 胎盘植入性疾病患者行子宫部分切除术后再次妊娠的临床研究[J]. 中华产科急救电子杂志, 2023, 12(03): 180-186.
[11] 刘育昕, 王子晗, 张艺馨, 栾永婕, 孟凯. 肾母细胞瘤基因1在卵巢疾病发病机制中的研究进展[J]. 中华诊断学电子杂志, 2023, 11(03): 178-183.
[12] 王正宇, 孙琳. 硒联合不同药物治疗桥本甲状腺炎的研究进展[J]. 中华诊断学电子杂志, 2023, 11(02): 125-127.
[13] 何亚伟, 陈皖京, 宋佳宏, 于刚, 贾犇黎, 汪泳. 肥胖患者SCH、血清维生素D水平与NAFLD严重程度关系的研究[J]. 中华肥胖与代谢病电子杂志, 2023, 09(02): 95-101.
[14] 张佳玉, 丁玉兰, 郑旋玲, 刘长勤. 睡眠障碍对多囊卵巢综合征不良影响的研究进展[J]. 中华肥胖与代谢病电子杂志, 2023, 09(02): 131-136.
[15] 俞刘珍雄, 张康睿, 杨若蕊, 刘学春, 王龙, 吴竹青, 吴君仓. 维生素D水平与接受静脉溶栓治疗的缺血性卒中患者预后的关系[J]. 中华脑血管病杂志(电子版), 2023, 17(02): 94-101.
阅读次数
全文


摘要