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中华临床医师杂志(电子版) ›› 2021, Vol. 15 ›› Issue (05) : 388 -392. doi: 10.3877/cma.j.issn.1674-0785.2021.05.014

综述

肥厚型心肌病发生心房颤动的危险因素研究进展
王娟1, 杨艳敏1,()   
  1. 1. 100037 北京,国家心血管病中心 中国医学科学院 阜外医院急重症中心
  • 收稿日期:2020-12-13 出版日期:2021-05-15
  • 通信作者: 杨艳敏
  • 基金资助:
    国家重点研发计划(2017YFC0908800)

Progress in research of risk factors for atrial fibrillation in hypertrophic cardiomyopathy

Juan Wang1, Yanmin Yang1,()   

  1. 1. Emergency and Intensive Care Center, National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037, China
  • Received:2020-12-13 Published:2021-05-15
  • Corresponding author: Yanmin Yang
引用本文:

王娟, 杨艳敏. 肥厚型心肌病发生心房颤动的危险因素研究进展[J]. 中华临床医师杂志(电子版), 2021, 15(05): 388-392.

Juan Wang, Yanmin Yang. Progress in research of risk factors for atrial fibrillation in hypertrophic cardiomyopathy[J]. Chinese Journal of Clinicians(Electronic Edition), 2021, 15(05): 388-392.

心房颤动(AF)是肥厚型心肌病(HCM)最常见的心律失常之一,HCM患者对AF的耐受性较差,发生AF的HCM患者的死亡率、致残率和血栓栓塞事件发生率显著增加,及早而准确识别发生AF的危险因素,进行早期干预和治疗,可显著改善此类患者的预后。本文就HCM发生AF特有的危险因素做一综述。

Atrial fibrillation (AF) is the most common arrhythmia in hypertrophic cardiomyopathy (HCM). Patients with HCM have poor tolerance to AF, and patients with HCM and AF have significantly increased risk of mortality and thromboembolic events. Early and accurate identification of the possible risk factors and mechanisms of AF as well as early intervention and treatment can significantly improve the prognosis of such patients. This article reviews the risk factors for AF in HCM.

图1 HCM发生AF的危险因素及管理策略
1
Elliott PM, Anastasakis A, Borger MA, et al. 2014 ESC guidelines on diagnosis and management of hypertrophic cardiomyopathy: the task force for the diagnosis and management of hypertrophic cardiomyopathy of the European society of cardiology (ESC) [J]. Eur Heart J, 2014, 35(39): 2733-2779.
2
Maron BJ, Rowin EJ, Maron MS. Global burden of hypertrophic cardiomyopathy [J]. JACC Heart Failure, 2018, 6(5): 376-378.
3
中华医学会心血管病学分会中国成人肥厚型心肌病诊断与治疗指南编写组, 中华心血管病杂志编辑委员会. 中国成人肥厚型心肌病诊断与治疗指南 [J]. 中华心血管病杂志, 2017, 45(12): 1015-1032.
4
Philipson DJ, Rader F, Siegel RJ. Risk factors for atrial fibrillation in hypertrophic cardiomyopathy [J]. Eur J Prev Cardiol, 2021,28(6):658-665.
5
Guttmann OP, Pavlou M, O'Mahony C, et al. Predictors of atrial fibrillation in hypertrophic cardiomyopathy [J]. Heart, 2017, 103(9): 672-678.
6
Rowin EJ, Hausvater A, Link MS, et al. Clinical profile and consequences of atrial fibrillation in hypertrophic cardiomyopathy [J]. Circulation, 2017, 136(25): 2420-2436.
7
Gruver EJ, Fatkin D, Dodds GA, et al. Familial hypertrophic cardiomyopathy and atrial fibrillation caused by Arg663His beta-cardiac myosin heavy chain mutation [J]. Am J Cardiol, 1999, 83(12A): 13H-18H.
8
Lee S, Ashley EA, Homburger J, et al. Incident atrial fibrillation is associated with MYH7 sarcomeric gene variation in hypertrophic cardiomyopathy [J]. Circ Heart Fail, 2018,11(9): e005191.
9
Ho CY, López B, Coelho-Filho OR, et al. Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy [J]. N Engl J Med, 2010, 363(6): 552-563.
10
Girolami F, Iascone M, Tomberli B, et al. Novel alpha-actinin 2 variant associated with familial hypertrophic cardiomyopathy and juvenile atrial arrhythmias: a massively parallel sequencing study [J]. Circ Cardiovasc Genet, 2014, 7(6): 741-750.
11
Belenkov YN, Privalova EV, Kaplunova VY, et al. Analysis of morpho-functional parameters of the heart and polymorphisms of renin-angiotensin-aldosterone system genes in patients with different variants of the course of hypertrophic cardiomyopathy [J]. Kardiologiia, 2010, 50(6): 27-34.
12
Orenes-Pinero E, Hernandez-Romero D, Romero-Aniorte AI, et al. Prognostic value of two polymorphisms in non-sarcomeric genes for the development of atrial fibrillation in patients with hypertrophic cardiomyopathy [J]. QJM, 2014, 107(8): 613-621.
13
Haruki S, Minami Y, Hagiwara N. Stroke and embolic events in hypertrophic cardiomyopathy: risk stratification in patients without atrial fibrillation [J]. Stroke, 2016, 47(4): 936-942.
14
Guttmann OP, Rahman MS, O'Mahony C, et al. Atrial fibrillation and thromboembolism in patients with hypertrophic cardiomyopathy: systematic review [J]. Heart, 2014, 100(6): 465-472.
15
Debonnaire P, Joyce E, Hiemstra Y, et al. Left atrial size and function in hypertrophic cardiomyopathy patients and risk of new-onset atrial fibrillation [J]. Circ Arrhythm Electrophysiol, 2017, 10(2):e004052.
16
Fukumoto K, Habibi M, Ipek EG, et al. Association of left atrial local conduction velocity with late gadolinium enhancement on cardiac magnetic resonance in patients with atrial fibrillation [J]. Circ Arrhythm Electrophysiol, 2016, 9(3): e2897.
17
Kuppahally SS, Akoum N, Burgon NS, et al. Left atrial strain and strain rate in patients with paroxysmal and persistent atrial fibrillation: relationship to left atrial structural remodeling detected by delayed-enhancement MRI [J]. Circ Cardiovasc Imaging, 2010, 3(3): 231-239.
18
Sivalokanathan S, Zghaib T, Greenland GV, et al. Hypertrophic cardiomyopathy patients with paroxysmal atrial fibrillation have a high burden of left atrial fibrosis by cardiac magnetic resonance imaging [J] JACC Clin Electrophysiol, 2019, 5(3): 364-375.
19
Cecchi F, Montereggi A, Olivotto I, et al. Risk for atrial fibrillation in patients with hypertrophic cardiomyopathy assessed by signal averaged P wave duration [J]. Heart, 1997, 78(1): 44-49.
20
Tuluce K, Yakar TS, Kahya EN, et al. Predictors of future atrial fibrillation development in patients with hypertrophic cardiomyopathy: a prospective follow-up study [J]. Echocardiography, 2016, 33(3): 379-385.
21
Ozdemir O, Soylu M, Demir AD, et al. P-wave durations as a predictor for atrial fibrillation development in patients with hypertrophic cardiomyopathy [J]. Int J Cardiol, 2004, 94(2-3): 163-166.
22
Farhad H, Seidelmann SB, Vigneault D, et al. Left atrial structure and function in hypertrophic cardiomyopathy sarcomere mutation carriers with and without left ventricular hypertrophy [J]. J Cardiovasc Magn Reson, 2017, 19(1): 107.
23
Debonnaire P, Joyce E, Hiemstra Y, et al. Left atrial size and function in hypertrophic cardiomyopathy patients and risk of new-onset atrial fibrillation [J]. Circ Arrhythm Electrophysiol, 2017, 10(2): e004052.
24
Maron BJ, Haas TS, Maron MS, et al. Left atrial remodeling in hypertrophic cardiomyopathy and susceptibility markers for atrial fibrillation identified by cardiovascular magnetic resonance [J]. Am J Cardiol, 2014, 113(8): 1394-1400.
25
Paraskevaidis IA, Farmakis D, Papadopoulos C, et al. Two-dimensional strain analysis in patients with hypertrophic cardiomyopathy and normal systolic function: a 12-month follow-up study [J]. Am Heart J, 2009, 158(3): 444-450.
26
Paraskevaidis IA, Panou F, Papadopoulos C, et al. Evaluation of left atrial longitudinal function in patients with hypertrophic cardiomyopathy: a tissue Doppler imaging and two-dimensional strain study [J]. Heart, 2009, 95(6): 483-489.
27
Girasis C, Vassilikos V, Efthimiadis GK, et al. Patients with hypertrophic cardiomyopathy at risk for paroxysmal atrial fibrillation: advanced echocardiographic evaluation of the left atrium combined with non-invasive P-wave analysis [J]. Eur Heart J Cardiovasc Imaging, 2013, 14(5): 425-434.
28
Garg L, Gupta M, Sabzwari SRA, et al. Atrial fibrillation in hypertrophic cardiomyopathy: prevalence, clinical impact, and management [J]. Heart Fail Rev, 2019, 24(2): 189-197.
29
Pedrosa RP, Drager LF, Genta PR, et al. Obstructive sleep apnea is common and independently associated with atrial fibrillation in patients with hypertrophic cardiomyopathy [J]. Chest, 2010, 137(5): 1078-1084.
30
Oliveira W, Campos O, Bezerra LE, et al. Left atrial volume and function in patients with obstructive sleep apnea assessed by real-time three-dimensional echocardiography [J]. J Am Soc Echocardiogr, 2008, 21(12): 1355-1361.
31
Van Wagoner DR, Chung MK. Inflammation, inflammasome activation, and atrial fibrillation [J]. Circulation, 2018, 138(20): 2243-2246.
32
Liu L, Wu L, Zheng L, et al. Associations between multiple circulating biomarkers and the presence of atrial fibrillation in hypertrophic cardiomyopathy with or without left ventricular outflow tract obstruction [J]. Int Heart J, 2019, 60(2):327-335.
33
Fang L, Ellims AH, Beale AL, et al. Systemic inflammation is associated with myocardial fibrosis, diastolic dysfunction, and cardiac hypertrophy in patients with hypertrophic cardiomyopathy [J]. Am J Transl Res, 2017, 9(11): 5063.
34
Baumgartner C, Da CB, Collet TH, et al. Thyroid function within the normal range, subclinical hypothyroidism, and the risk of atrial fibrillation [J]. Circulation, 2017, 136(22): 2100-2116.
35
孟祥彬. 甲状腺功能对肥厚型心肌病患者发生房颤以及远期预后的影响 [D]. 郑州: 郑州大学, 2018.
36
Liu LM, Shen LS, Liu SY, et al. Correlations between low thyroid function and incidence of atrial fibrillation in hypertrophic obstructive cardiomyopathy [J]. Chronic Dis Transl Med, 2020, 6(1): 35-45.
37
Liu L, Yun F, Zhao H, et al. Atrial sympathetic remodeling in experimental hyperthyroidism and hypothyroidism rats [J]. Int J Cardiol, 2015, 187: 148-150.
38
Zhang Y, Dedkov EI, Teplitsky D, et al. Both hypothyroidism and hyperthyroidism increase atrial fibrillation inducibility in rats [J]. Circ Arrhythm Electrophysiol, 2013, 6(5): 952-959.
39
Siontis KC, Geske JB, Ong K, et al. Atrial fibrillation in hypertrophic cardiomyopathy: prevalence, clinical correlations, and mortality in a large high-risk population [J]. J Am Heart Assoc, 2014, 3(3): e1002.
40
Tuluce K, Yakar TS, Kahya EN, et al. Predictors of future atrial fibrillation development in patients with hypertrophic cardiomyopathy: a prospective follow-up study [J]. Echocardiography, 2016, 33(3): 379-385.
41
Mayyas F, Niebauer M, Zurick A, et al. Association of left atrial endothelin-1 with atrial rhythm, size, and fibrosis in patients with structural heart disease [J]. Circ Arrhythm Electrophysiol, 2010, 3(4): 369-379.
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