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中华临床医师杂志(电子版) ›› 2021, Vol. 15 ›› Issue (11) : 814 -818. doi: 10.3877/cma.j.issn.1674-0785.2021.11.003

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溃疡性结肠炎相关结直肠癌的外科治疗
何安琪1, 刘刚1,()   
  1. 1. 300052 天津,天津医科大学总医院普通外科
  • 收稿日期:2021-07-19 出版日期:2021-11-15
  • 通信作者: 刘刚

Surgical management of ulcerative colitis related colorectal cancer

Anqi He1, Gang Liu1,()   

  1. 1. Department of General Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China
  • Received:2021-07-19 Published:2021-11-15
  • Corresponding author: Gang Liu
引用本文:

何安琪, 刘刚. 溃疡性结肠炎相关结直肠癌的外科治疗[J/OL]. 中华临床医师杂志(电子版), 2021, 15(11): 814-818.

Anqi He, Gang Liu. Surgical management of ulcerative colitis related colorectal cancer[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2021, 15(11): 814-818.

溃疡性结肠炎(UC)是慢性非特异性肠道炎症性疾病,长期反复炎症刺激下的上皮细胞损伤、修复和增殖使UC患者具有更高肠道黏膜癌变风险。溃疡性结肠炎相关性结直肠癌(UC-CRC)是UC的重要并发症,也是其外科手术治疗的绝对适应证。全结直肠切除、回肠贮袋肛管吻合术(IPAA)是治疗UC的标准术式,也适用于经过筛选的UC-CRC患者。UC-CRC外科治疗应以肿瘤根治原则为基石,结合UC疾病特点和患者全身状况对每例患者进行个体化的治疗方案制定,是改善肿瘤预后并提高生活质量的总体策略。

Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease of the intestine. The damage, repair, and proliferation of epithelial cells stimulated by long-term recurrent inflammation put UC patients at a higher risk of intestinal mucosal carcinogenesis. Ulcerative colitis related colorectal cancer (UC-CRC) is an important complication of UC, as well as an absolute indication for surgical treatment. Total colorectal resection and ileal pouch anal anastomosis are the standard surgeries for UC, and are also applicable to the screening of UC-CRC cases. Guided by the principles of radical tumor surgery and based on the disease characteristics and medical conditions, individualized treatment plan should be formulated to improve the prognosis and quality of life of UC-CRC patients.

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