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中华临床医师杂志(电子版) ›› 2025, Vol. 19 ›› Issue (07) : 536 -543. doi: 10.3877/cma.j.issn.1674-0785.2025.07.009

综述

肺挫伤病理生理机制及相关治疗研究
俞若婷, 高威(), 刘宇浩, 刘琛   
  1. 430000 武汉,武汉科技大学附属天佑医院心胸外科
  • 收稿日期:2025-07-22 出版日期:2025-07-30
  • 通信作者: 高威
  • 基金资助:
    湖北省教育厅科学研究计划(B2022003); 武汉科技大学2024年研究生创新创业基金(JCX2024040)

Pathophysiological mechanisms and therapeutic advances in pulmonary contusion

Ruoting Yu, Wei Gao(), Yuhao Liu, Chen Liu   

  1. Department of Cardiothoracic Surgery, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan 430000, China
  • Received:2025-07-22 Published:2025-07-30
  • Corresponding author: Wei Gao
引用本文:

俞若婷, 高威, 刘宇浩, 刘琛. 肺挫伤病理生理机制及相关治疗研究[J/OL]. 中华临床医师杂志(电子版), 2025, 19(07): 536-543.

Ruoting Yu, Wei Gao, Yuhao Liu, Chen Liu. Pathophysiological mechanisms and therapeutic advances in pulmonary contusion[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2025, 19(07): 536-543.

肺挫伤常继发于钝性胸外伤,其严重程度与患者的死亡率及预后都有重要关联。本文从肺挫伤中的肺组织、细胞及细胞因子、花生四烯酸代谢物、活性氧(ROS)、补体系统与凝血级联等方面进行阐述,深入肺损伤的炎症网络,叙述肺挫伤的病情发展,概括目前肺挫伤炎症病理生理机制研究发现与治疗进展,将调控靶点与临床治疗结合,干预肺挫伤的病程进展,改善预后。

Pulmonary contusion, a common consequence of blunt chest trauma, exhibits a mortality and prognostic profile strongly linked to its severity. This article synthesizes current knowledge on the pathophysiological mechanisms of pulmonary contusion, encompassing lung tissue damage, cellular and cytokine responses, arachidonic acid metabolites, reactive oxygen species, the complement system, and the coagulation cascad. By elucidating this complex inflammatory network, we aim to bridge fundamental research with clinical practice. Furthermore, we summarize recent advances in understanding these mechanisms and discuss emerging treatment strategies that target them, with the ultimate goal of improving patient outcomes through timely intervention.

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