Effect of high glucose on cardiovascular system: application of nicorandil in cardiovascular disease

doi:10.3877/cma.j.issn.1674-0785.2017.21.005

Abstract

Abstract:

Coronary heart disease threatens the people's health seriously, especially when it is accompanied with diabetes mellitus. Diabetes mellitus can lead to macroangiopathy and microangiopathy, which manifest as vascular endothelial injury in the cardiovascular system and can lead to or exacerbate the process of atherosclerosis and myocardial apoptosis. Many studies indicate that oxidative stress, inflammatory reaction, and endoplasmic reticulum stress are the probable mechanisms, and therefore antagonizing these factors is of particular significance. Nicorandil, a new cardiovascular drug, plays an important role in vasodilation and cardioprotection and can improve the endothelial function.

Key words: Diabetes mellitus, Oxidative stress, Endoplasmic reticulum stress, Apoptosis, Nicorandil

Yuqing Zhao, Yingru Chai, Li Jiang, Guoxia An, Yan Chai. Effect of high glucose on cardiovascular system: application of nicorandil in cardiovascular disease[J]. Chinese Journal of Clinicians(Electronic Edition), 2017, 11(21): 2373-2376.

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