Vascular endothelial progenitor cells: biological activity and capture stents

doi:10.3877/cma.j.issn.1674-0785.2018.02.013

Abstract

Abstract:

Vascular endothelial progenitor cells (EPCs) act as precursor cells of endothelial cells and have the ability of persistent self-renewal and directed differentiation. EPC capture stents, coated with CD34⁺ antibody, can recognize the exposed binding sites on the surface of EPCs, capture EPCs and promote them to home and differentiate into endothelial cells, participate in vascular endothelial repair, and facilitate angiogenesis to improve coronary blood flow. Studies have shown that the biological activity of EPCs is key to the clinical application of EPC capture stents. In this paper, we summarize the biological characteristics and function of EPCs and the regulatory effect of coronary artery microenvironment on EPCs, and review the progress in research of EPC capture stents to explore their therapeutic value.

Key words: Endothelial progenitor cells, Capture stents, Coronary atherosclerosis microenvironment

Jing Tian, yi An, Fei Yu, Xianming Chu. Vascular endothelial progenitor cells: biological activity and capture stents[J]. Chinese Journal of Clinicians(Electronic Edition), 2018, 12(02): 119-122.

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