Relationship between CD40 -1C/T single nucleotide polymorphism and ischemic stroke susceptibility: a review of recent advances

doi:10.3877/cma.j.issn.1674-0785.2018.02.014

Abstract

Abstract:

The occurrence of ischemic stroke is influenced by a variety of genetic and environmental factors. Atherosclerosis is an important pathologic and physiological basis for the development of ischemic stroke. The CD40/CD40 ligand (CD40L) system and serum soluble CD40 ligand (sCD40L) are involved in inflammatory processes such as atherosclerosis, and can affect the development and progression of ischemic stroke. The single nucleotide polymorphism CD40 -1C/T might contribute to susceptibility to ischemic stroke by regulating the CD40/CD40L system and the expression of sCD40L. This paper reviews the recent progress in the understanding of the association between CD40 -1C/T single nucleotide polymorphism and ischemic stroke susceptibility.

Key words: CD40-1C/T, Single nucleotide, Polymorphism, Stroke, Ischemic, CD40/CD40L, Arteriosclerosis

Wenhui Duan, Dongfang Li, Jingwen Zhang, Tao Lu, Zhen Sun. Relationship between CD40 -1C/T single nucleotide polymorphism and ischemic stroke susceptibility: a review of recent advances[J]. Chinese Journal of Clinicians(Electronic Edition), 2018, 12(02): 123-126.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhlcyszz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0785.2018.02.014

https://zhlcyszz.cma-cmc.com.cn/EN/Y2018/V12/I02/123

References 35

1	Meschia JF, Worrall BB, Rich SS. Genetic susceptibility to ischemic stroke [J]. Nat Rev Neurol, 2011, 7(7): 369-378.
2	Shamsara J, Mohammadpour AH, Behravan J, et al. Pentoxifylline decreases soluble CD40 ligand concentration and CD40 gene expression in coronary artery disease patients [J]. Immunopharmacol Immunotoxicol, 2012, 34(3): 523-529.
3	Antoniades C, Bakogiannis C, Tousoulis D, et al. The CD40/CD40 ligand system: linking inflammation with atherothrombosis [J]. J Am Coll Cardiol, 2009, 54(8): 669-677.
4	Pamukcu B, Lip GY, Snezhitskiy V, et al. The CD40-CD40L system in cardiovascular disease [J]. Ann Med, 2011, 43(5): 331-340.
5	García-Bermúdez M, González-Juanatey C, López-Mejías R, et al. AB0021 Study of association of CD40-CD154 gene polymorphisms with disease susceptibility and cardiovascular risk in spanish rheumatoid arthritis patients [J]. PLoS One, 2012, 7(11): e49214.
6	Schönbeck U, Libby P. CD40 signaling and plaque instability [J]. Circ Res, 2001, 89(12): 1092-1103.
7	Tian C, Qin W, Li L, et al. A common polymorphism in CD40 Kozak sequence (-1C/T) is associated with acute coronary syndrome [J]. Biomed Pharmacother, 2010, 64(3): 191-194.
8	Wang M, Li Y, Li W, et al. The CD40 gene polymorphism rs1883832 is associated with risk of acute coronary syndrome in a Chinese case-control study [J]. DNA Cell Biol, 2011, 30(3): 173-178.
9	Fong SW, Few LL, See Too WC, et al. Systemic and coronary levels of CRP, MPO, sCD40L and PlGF in patients with coronary artery disease [J]. BMC Res Notes, 2015, 8: 679.
10	YanYun P, Wang S, Yang J, et al. Interruption of CD40 pathway improves efficacy of transplanted endothelial progenitor cells in monocrotaline induced pulmonary arterial hypertension [J]. Cell Physiol Biochem, 2015, 36(2): 683-696.
11	Nakayama Y, Brinkman CC, Bromberg JS. Murine fibroblastic reticular cells from lymph node interact with CD4⁺ T cells through CD40-CD40L [J]. Transplantation, 2015, 99(8): 1561-1567.
12	Wang DG, Fan JB, Siao CJ, et al. Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome [J]. Science, 1998, 280(5366): 1077-1082.
13	Chen JM, Guo J, Wei CD, et al. The association of CD40 polymorphisms with CD40 serum levels and risk of systemic lupus erythematosus [J]. BMC Genet, 2015, 16: 121.
14	Sokolova EA, Malkova NA, Korobko DS, et al. Association of SNPs of CD40 gene with multiple sclerosis in russians [J]. PLoS One, 2013, 8(4): e61032.
15	Zhou C, Jin X, Tang J, et al. Association of CD40 -1C/T polymorphism in the 5′-untranslated region with chronic HBV infection [J]. Cell Physiol Biochem, 2015, 35(1): 83-91.
16	Ma Y, Wang SX, Liu Y, et al. Single nucleotide polymorphism of CD40 in the 5′-untranslated region is associated with ischemic stroke [J]. Gene, 2013, 529(2): 257-261.
17	Jacobson EM, Concepcion E, Oashi T, et al. A Graves′ disease-associated Kozak sequence single-nucleotide polymorphism enhances the efficiency of CD40 gene translation: a case for translational pathophysiology [J]. Endocrinology, 2005, 146(6): 2684-2691.
18	Zhang B, Wu T, Song C, et al. Association of CD40-1C/T polymorphism with cerebral infarction susceptibility and its effect on sCD40L in Chinese population [J]. Int Immunopharmacol, 2013, 16(4): 461-465.
19	陈健明, 黄华佗, 袁秋然, 等. 白细胞分化抗原-40基因SNP及其血清水平与缺血性脑卒中的相关性 [J]. 中华预防医学杂志, 2016, 50(3): 239-243.
20	Huang HT, Guo J, Xiang Y, et al. A SNP in 5′untranslated region of CD40 gene is associated with an increased risk of ischemic stroke in a Chinese population: a case-control study [J]. Genet Mol Biol, 2017, 40(2): 442-449.
21	Zhang B, Chen M, Yang H, et al. Evidence for involvement of the CD40/CD40L system in post-stroke epilepsy [J]. Neurosci Lett, 2014, 567(5): 6-10.
22	del Río-Espínola A, Fernández-Cadenas I, Rubiera M, et al. CD40-1C>T polymorphism (rs1883832) is associated with brain vessel reocclusion after fibrinolysis in ischemic stroke [J]. Pharmacogenomics, 2010, 11(6): 763-772.
23	Kassner SS, Kollmar R, Bonaterra GA, et al. The early immunological response to acute ischemic stroke: differential gene expression in subpopulations of mononuclear cells [J]. Neuroscience, 2009, 160(2): 394-401.
24	Garlichs CD, Kozina S, Fateh-Moghadam S, et al. Upregulation of CD40-CD40 ligand (CD154) in patients with acute cerebral ischemia [J]. Stroke, 2003, 34(6): 1412-1418.
25	Chen Y, Chen J, Xiong Y, et al. Internalization of CD40 regulates its signal transduction in vascular endothelial cells [J]. Biochem Biophys Res Commun, 2006, 345(1): 106-117.
26	de Lemos JA, Zirlik A, Schönbeck U, et al. Associations between soluble CD40 ligand, atherosclerosis risk factors, and subclinical atherosclerosis: results from the Dallas Heart Study [J]. Arterioscler Thromb Vasc Biol, 2005, 25(10): 2192-2196.
27	Tuttolomondo A, Di Raimondo D, Di Sciacca R, et al. Fetuin-A and CD40 L plasma levels in acute ischemic stroke: Differences in relation to TOAST subtype and correlation with clinical and laboratory variables [J]. Atherosclerosis, 2010, 208(1): 290-296.
28	Lukasik M, Dworacki G, Michalak S, et al. Chronic hyper-reactivity of platelets resulting in enhanced monocyte recruitment in patients after ischaemic stroke [J]. Platelets, 2012, 23(2): 132-142.
29	Wang JH, Zhang YW, Zhang P, et al. CD40 ligand as a potential biomarker for atherosclerotic instability [J]. Neurol Res, 2013, 35(7): 693-700.
30	Lorente L, Martín MM, González-Rivero AF, et al. Association between serum soluble CD154 levels and mortality in patients with malignant middle cerebral artery infarction [J]. Int J Mol Sci, 2015, 16(6): 12147-12158.
31	Wang Y, Zhao X, Liu L, et al. Prevalence and outcomes of symptomatic intracranial large artery stenoses and occlusions in China: the Chinese Intracranial Atherosclerosis (CICAS) Study [J]. Stroke, 2014, 45(3): 663-669.
32	Wang YJ, Gong ZQ, Bi XM, et al. Correlation of plasma soluble cluster of differentiation 40 ligand, alpha fetoprotein A, and pregnancy-associated plasma protein A with carotid plaque in patients with ischemic stroke [J]. Genet Mol Res, 2015, 14(3): 8091-8099.
33	Li J, Wang Y, Lin J, et al. Soluble CD40L is a useful marker to predict future strokes in patients with minor stroke and transient ischemic attack [J]. Stroke, 2015, 46(7): 1990-1992.
34	Ma Y, Wang SX, Liu Y, et al. Single nucleotide polymorphism of CD40 in the 5′-untranslated region is associated with ischemic stroke [J]. Gene, 2013, 529(2): 257-261.
35	马丽书, 李东芳. CD40-1C/T基因多态性与大动脉粥样硬化性卒中的相关性 [J]. 国际脑血管病杂志, 2012, 20(3): 177-181.

[1]	Wei Fu, Jie Li, Lin Ma, Yanmin Kan. Evaluation of carotid arterial elasticity using ultrafast pulse wave velocity in patients with isolated systolic hypertension [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2019, 16(09): 671-675.
[2]	Wulong Wu, Zezhou Song, Yanming Zhang, Yanfei Fu, Yu Geng. The prediction of recurrent cerebral infarction by the neovascularization grade of carotid plaque using contrast enhanced ultrasonography: a Logistic regression model analysis [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2018, 15(01): 43-47.
[3]	Luping Ouyang, Xiuyun Qin, Hui Wei, Shang Yi, Yue Zhang, Baoheng Gui. Application values of single nucleotide polymorphism array technology in prenatal diagnosis of fetal lateral ventriculomegaly [J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2020, 16(03): 322-328.
[4]	Youjun Mao, Xiaoqiang Li. Diagnosis and treatment of in-stent restenosis of lower extremity artery [J]. Chinese Archives of General Surgery(Electronic Edition), 2020, 14(01): 76-80.
[5]	Qiangqiang Li, Xiaobo Yu, Lin Zhou, Hong Li, Zhenglong Zhai, Shusen Zheng. Predictive value of YTHDF1 single nucleotide polymorphism in the hepatocellular carcinoma recurrence of liver transplant recipients within the Hangzhou criteria [J]. Chinese Journal of Transplantation(Electronic Edition), 2020, 14(06): 337-342.
[6]	Tianyong Wu, Hongbin Chen, Dan Cheng. Meta-analysis on relationship between HHIP rs13118928 single nucleotide polymorphism and susceptibility to chronic obstructive pulmonary disease [J]. Chinese Journal of Lung Diseases(Electronic Edition), 2019, 12(04): 420-425.
[7]	Haicheng She, Shenshen Yan, Pengfei Sun, Yimeng Jiang, Fangfang Fan, Jia Jia, Yan Zhang. The relationship between triglyceride glucose index and retinal arteriosclerosis grading in a community-based population [J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2021, 11(05): 262-267.
[8]	Xiaotong Yu, Zhengyu Wang, Chen Huang, Huibin Lyn, Mingzhou Zhang, Xuemin Li. High-risk pathogenic phenotype predictions of non-synonymous single nucleotide polymorphisms in human heat shock transcription factor 4 gene associated with congenital cataract [J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2019, 09(02): 96-104.
[9]	Bo Song, Yun Cheng, Yuzhang Jiang, Chong Shen, Yong Xue, Yinghui Li. Association study between microRNA-938 and TGFBR1 single nucleotide polymorphisms and hemorrhagic stroke [J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2019, 09(04): 205-209.
[10]	Ziyu Liu, Surong Wen, Xiaoqing Wang, Xing Qi, Hairong Hao, Yanwen Lu, Jing Li, Shayan Li, Weinan Yu, Hongwen Zhou, Wen Hu. Effect of PPM1K gene single nucleotide polymorphisms rs1440581 and rs7678928 on serum branched chain amino acid levels and subsequent cardiovascular disease risk [J]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(12): 953-961.
[11]	Sheng Guan, Jianping Yang, Jiareke Tang, Xiaohu Ge. Efficacy of Turbo Hawk atherectomy system in treatment of lower extremity arteriosclerosis obliterans [J]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(04): 272-276.
[12]	Qiuhong Zou, Haiyan Li. Perioperative observation and nursing care of patients with arteriosclerosis obliterans of lower limbs treated by plaque circumcision and volume reduction technique [J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2022, 10(02): 215-218.
[13]	Lianghong Ni, Xiangkui Wang, Chunyan Zhao. Clinical study of POSSUM score combined with APACHE II score on interventional therapy of lower extremity arteriosclerosis obliterans [J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2019, 07(01): 21-25.
[14]	Xingjie Wu, Shugui Huang, Jun Deng, Jun Li, Ping Fang, Wei Zhu. Clinical effects of angioplasty combined with catheterized thrombolysis in treatment of arteriosclerosis obliterans of lower extremities [J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2018, 06(03): 232-236.
[15]	Qiang Chen, Bingjie Zuo, Yan Liu, Lei Su, Guohua Sun. Analysis of risk factors for arteriosclerosis renal artery stenosis [J]. Chinese Journal of Geriatrics Research(Electronic Edition), 2020, 07(02): 36-39.

Please choose a citation manager

Content to export