Role of exosomes in carcinogenesis and diagnosis of breast cancer

doi:10.3877/cma.j.issn.1674-0785.2018.07.008

Abstract

Abstract:

Breast cancer is the most common malignant tumor in women, which has a complex pathogenesis. According to the latest research, the role of exosomes in tumorigenesis has become the focus of research. Exosomes, one of the circulating vesicles, can promote the occurrence, development, invasion and metastasis of breast cancer and other tumors through exosome-mediated intercellular communication, which shows great value in understanding the process of carcinogenesis and clinical diagnosis and treatment. Therefore, we review the structure and function of exosomes and their role in the tumorigenesis, diagnosis and treatment of breast cancer, in order to help clinicians better understand the pathogenesis of breast cancer and provide a new clue to the clinical diagnosis and treatment of this malignancy.

Key words: Exosomes, Breast cancer, Biomarkers, Diagnosis, Treatment

Hanyu Yao, Zhengquan Zhang, Yunpeng Hu, Xueying Wang, Deyuan Fu. Role of exosomes in carcinogenesis and diagnosis of breast cancer[J]. Chinese Journal of Clinicians(Electronic Edition), 2018, 12(07): 410-413.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhlcyszz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0785.2018.07.008

https://zhlcyszz.cma-cmc.com.cn/EN/Y2018/V12/I07/410

References 37

1	Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016 [J]. CA Cancer, 2016, 66(1):7-30.
2	Chen W, Zheng R, Baade PD, et a1. Cancer statistics in China, 2015 [J]. CA Cancer, 2016, 66(2):115-132.
3	Petrakis IE, Paraskakis S. Breast cancer in the elderly [J]. Arch gerontol geriatr, 2010, 50(2):179-184.
4	Jia Y, Chen Y, Wang Q, et al. Exosome: emerging biomarker in breast cancer [J]. Oncotarget, 2017, 8(25):41717-41733.
5	Lobb RJ, van Amerongen R, Wiegmans A, et al. Exosomes derived from mesenchymal non-small cell lung cancer cells promote chemoresistance [J]. Int J Cancer, 2017, 141(3):614-620.
6	Franzen CA, Blackwell RH, Foreman KE, et al. Urinary exosomes: the potential for biomarker utility, intercellular signaling, and therapeutics in urologic malignancy [J]. J Urol, 2016, 195(5):1331-1339.
7	Tang XJ, Sun XY, Huang KM, et al. Therapeutic potential of CAR—T cell-derived exosomes: a cell-free modality for targeted cancer therapy [J]. Oncotarget, 2015, 6(42):44179-44190.
8	Nikitina IG, Sabirova EIu, Karpov VL, et al. The role of exosomes and microvesicles in carcinogenesis [J]. Mol Biol(Mosk). 2013, 47(5):767-773.
9	Sun Y, Liu J. Potential of cancer cell-derived exosomes in clinical application：a review of recent research advances [J]. Clin Ther, 2014, 36(6):863-872.
10	O′Brien K, Rani S, Corcoran C, et al. Exosomes from triple—negative breast cancer cells can transfer phenotypic traits representing their cells of origin to secondary cells [J]. Eur J Cancer, 2013, 49(8):1845-1859．
11	Keller S, König AK, Marmé F, et al. Systemic presence and tumor-growth promoting effect of ovarian carcinoma released exosomes [J]. Cancer Lett, 2009, 278(1):73-81.
12	Rodríguez M, Silva J, Herrera A, et al. Exosomesenriched in stemness/metastatic-related mRNAS promote oncogenic potential in breast cancer [J]. Oncotarget, 2015, 6(38):40575-40587.
13	Kannan A, Wells RB, Sivakumar S, et al. Mitochondrial reprogramming regulates breast cancer progression [J]. Clin Cancer Res, 2016, 22(13):3348-3360.
14	Harris DA, Patel SH, Gucek M, et al. Exosomes released from breast cancer carcinomas stimulate cell movement [J]. PLoS One, 2015, 10(3):e0117495.
15	Zhou W, Fong MY, Min Y, et al. Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis [J]. Cancer Cell, 2014, 25(4):501-515.
16	Yang M, Chen J, Su F, et al. Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells [J]. Mol Cancer, 2011, 10:117.
17	Singh R, Pochampally R, Watabe K, et al. Exosome-mediated transfer of miR-10b promotes cell invasion in breast cancer [J]. Mol Cancer, 2014, 13:256.
18	Shi J, Ren Y, Zhen L, et al. Exosomes from breast cancer cells stimulate proliferation and inhibit apoptosis of CD133+ cancer cells in vitro [J]. Mol Med Rep, 2015, 11(1):405-409.
19	Lin R, Wang S, Zhao RC. Exosomes from human adipose-derived mesenchymal stem cells promote migration through Wnt signaling pathway in a breast cancer cell model [J]. Mol Cell Biochem, 2013, 383(1-2):13-20.
20	Gorczynski RM, Erin N, Zhu F. Serum-derived exosomes from mice with highly metastatic breast cancer transfer increased metastatic capacity to a poorly metastatic tumor [J]. Cancer Med, 2016, 5(2):325-336.
21	Chen WX, Liu XM, Lv MM, et al. Exosomes from drugresistant breast cancer cells transmit chemoresistance by a horizontal transfer of microRNAs [J]. PLoS One, 2014, 9(4):e95240.
22	Chen WX, Cai YQ, Lv MM, et al. Exosomes from docetaxel-resistant breast cancer cells alter chemosensitivity by delivering microRNAs [J]. Tumour Biol, 2014, 35(10):9649-9659.
23	Yu DD, Wu Y, Zhang XH, et al. Exosomes from adriamycin-resistant breast cancer cells transmit drug resistance partly by delivering miR-222 [J]. Tumour Biol, 2016, 37(3):3227-3235.
24	Lv MM, Zhu XY, Chen WX, et al. Exosomes mediate drug resistance transfer in MCF-7 breast cancer cells and a probable mechanism is delivery of P-glycoprotein [J]. Tumour Biol, 2014, 35(11):10773-10779.
25	Ciravolo V, Huber V, Ghedini GC, et al. Potential role of HER2-overexpressing exosomes in countering trastuzumab-based therapy [J]. J Cell Physiol, 2012, 227(2):658667.
26	Skog J, Wurdinger T, van Rijn S, et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers [J]. Nat Cell Biol, 2008, 10(12):1470-1476.
27	Peinado H, Alečković M, Lavotshkin S, et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET [J]. Nat Med, 2012, 18(6):883-891.
28	Lan CS, Wong DT. Breast cancer exosome-like microvesicles and salivary gland cells interplay alters salivary gland cell--derived exosome-like mierovesieles in vitro [J]. PLoS One, 2012, 7(3):e33037.
29	Khan S, Bennit HF, Turay D, et al. Early diagnostic value of survivin and its alternative splice variants in breast cancer [J]. BMC Cancer, 2014, 14:176.
30	Melo SA, Luecke LB, Kahlert C, et al. Glypican-1 identifies cancer exosomes and detects early pancreatic cancer [J]. Nature, 2015, 523(7559):177-182.
31	Roberg-Larsen H, Lund K, Seterdal KE, et al. Mass spectrometric detection of 27-hydroxycholesterol in breast cancer exosomes [J]. J Steroid Biochem Mol Biol, 2017, 169:22-28.
32	盛湲，李恒宇. 外泌体:乳腺癌精确诊疗的新热点 [J/CD]. 中华乳腺病杂志(电子版), 2016, 10(3):133-136.
33	Tian Y, Li S, Song J, et al. A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy [J]. Biomaterials, 2014, 35(7):2383-2390.
34	Ohno S, Takanashi M, Sudo K, et al. Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells [J]. Mol Ther, 2013, 21(1):185-191.
35	Hadla M, Palazzolo S, Corona G, et al. Exosomes increase the therapeutic index of doxorubicin in breast and ovarian cancer mouse models [J]. Nanomedicine(Lond), 2016, 11(18):2431-2441.
36	Marleau AM, Chen CS, Joyce JA, et al. Exosome removal as a therapeutic adjuvant in cancer [J]. J Transl Med, 2012, 10:134.
37	Tan A, De La Peña H, Seifalian AM. The application of exosomes as a nanoscale cancer vaccine [J]. Int J Nanomedicine, 2010, 5:889-900.

[1]	Shuihua Yang, Guidan He, Guican Qin, Mengfeng Liang, Yanhe Luo, Xueqin Li, Juansong Tang. Echocardioimagedata characteristics of fetal isolated total anomalous pulmonary venous connection and application of high definition flow imaging and spatio-temporal image correlation [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2023, 20(10): 1061-1067.
[2]	Hua Shao, Ziyue Na, Hui Jing, Bo Li, Qiucheng Wang, Wen Cheng. Value of preoperative percutaneous contrast-enhanced ultrasound in diagnosis of axillary sentinel lymph node metastasis and burden in breast cancer [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2023, 20(08): 849-853.
[3]	Xu Zhang, Jianping Xu, Dongming Su, Caifen Wang, Dali Wang, Wenzhi Zhang. Contrast-enhanced ultrasound features of male breast masses [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2023, 20(08): 854-859.
[4]	Heng Lyu, Licong Dong, Haiqin Xie, Zhuofei Zhao, Li Liu, Desheng Sun. CT-ultrasound comparison for evaluating missed diagnosis of focal liver lesions by ultrasound: a single-center cross-sectional quality control survey [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2023, 20(07): 712-716.
[5]	Wei Zhang. Dentoalveolar surgery: The pioneer of comfortable treatment [J]. Chinese Journal of Stomatological Research(Electronic Edition), 2023, 17(06): 386-388.
[6]	Yi He, Dongsheng Yu. Advances in diagnosis and treatment of dislocation injury of young permanent teeth [J]. Chinese Journal of Stomatological Research(Electronic Edition), 2023, 17(06): 400-406.
[7]	Xu Peng, Yongfu Shao, Duo Li, Rui Zhou, Zhenming Xing. Diagnosis and surgical treatment of hepatocolon flexure [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(01): 108-110.
[8]	Weiqiang Ma, Binlin Ma, Zhongyu Wu, Ying Zhang. The role of microRNA in the progression of triple-negative breast cancer [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(01): 111-114.
[9]	bing Feng, Qiuguo Zou, Zhenbo Liang, Yanming Lu, Yi Zeng, Shumiao Wu. Clinical study of ultrasonic signs and molecular biological indicators of senile non-specific invasive breast cancer [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(01): 48-51.
[10]	Yansong Li, Huimin Feng, Mingchao Liu, Zepeng Liu, Qiuxia Jiang. Expression and clinical significance of STIP1 in triple negative breast cancer [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(01): 52-56.
[11]	Rongju Wu, Pingchao Xiang. Correlation between frequent exacerbation phenotype of chronic obstructive pulmonary disease and inflammatory markers [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(9): 939-947.
[12]	Zhifeng Lu, Jiajia Zhou, Shu Liang. Advances in application and research of virtual reality technology in amblyopia treatment [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(08): 891-895.
[13]	Tian Li, Hong Xu, Heliang Liu. Progress in research of pneumoconiosis [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(08): 900-905.
[14]	Fei Liu, Yingxin Wang, Xing Ma, Ling Xin, Yuanjia Cheng, Qian Liu, Yue Wang, Junjun Zhang. Different conductive media for intracavitary electrocardiogram-guided arm port implantation among breast cancer patients: a randomized controlled trial [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(07): 760-764.
[15]	Ruixue Yue, Lingxin Kong, Xin Hao, Jinqiang Yang, Meng Han, Guozhong Cui, Jianjun Wang, Zhisheng Zhang, Fanting Kong, Wei Zhang, Wenbo He, Xianqiao Li, Xinping Zhou, Donghong Xu, Chongzhu Hu. HER2 protein expression levels predict efficacy of neoadjuvant therapy in breast cancer: A real-world study [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(07): 765-770.

Please choose a citation manager

Content to export