Effect of radiofrequency ablation on serum FGF-21 level and cardiac function in patients with paroxysmal atrial fibrillation

doi:10.3877/cma.j.issn.1674-0785.2018.12.004

Abstract

Abstract:

Objective

To investigate the effect of radiofrequency ablation on serum FGF-21 level and cardiac function in patients with paroxysmal atrial fibrillation.

Methods

Eighty patients with paroxysmal atrial fibrillation treated at Qingdao Central Hospital from November 2015 to December 2017 were randomly divided into either a treatment group (40 cases) or a control group (40 cases). The control group was given comprehensive drug therapy, and the treatment group underwent RF ablation therapy. The two groups of patients were compared for left atrial diameter (LAD), right atrium diameter (RAD), left ventricular ejection fraction (LVEF%), and serum FGF-21 levels.

Results

LAD and RAD were significantly smaller in the treatment group than in the control group [(36.2±7.5) mm vs (42.5±8.3) mm, t=3.586, P<0.001; (35.3±7.2) mm vs (39.4±8.1) mm, t=2.393, P=0.019], and LVEF% was significantly better in the treatment group than in the control group [(59.3±8.2)% vs (52.1±7.5)%, t=4.098, P<0.001]. Seum FGF-21 level in the treatment group was significantly lower than that of the control group [(145.2±25.6) ng/L vs (197.6±30.4) ng/L, t=4.879, P<0.001].

Conclusion

Radiofrequency ablation can significantly decrease serum FGF-21 level and improve the heart function of patients with paroxysmal atrial fibrillation. Serum FGF-21 level may predict the cardiac function of patients with paroxysmal atrial fibrillation.

Key words: Radiofrequency ablation, Paroxysmal atrial fibrillation, Fibroblast growth factor-21, Cardiac function

Yan Wang, Dan Xu, Liwei Liu, Yuhong Wang. Effect of radiofrequency ablation on serum FGF-21 level and cardiac function in patients with paroxysmal atrial fibrillation[J]. Chinese Journal of Clinicians(Electronic Edition), 2018, 12(12): 669-672.

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组别	例数	年龄	吸烟	饮酒	糖尿病
治疗组	40	63.2±7.8	25（62.50）	23（57.50）	19（47.50）
对照组	40	66.7±12.3	23（57.50）	24（60.00）	20（50.00）
统计值	?	t=1.303	χ²=0.060	χ²=0.040	χ²=0.042
P值	?	0.126	0.689	0.841	0.838

组别	例数	年龄	吸烟	饮酒	糖尿病
治疗组	40	63.2±7.8	25（62.50）	23（57.50）	19（47.50）
对照组	40	66.7±12.3	23（57.50）	24（60.00）	20（50.00）
统计值	?	t=1.303	χ²=0.060	χ²=0.040	χ²=0.042
P值	?	0.126	0.689	0.841	0.838

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