Role of interleukin-17 in severe asthma

doi:10.3877/cma.j.issn.1674-0785.2019.02.013

Abstract

Abstract:

Asthma is a complex chronic inflammatory disease ranging from mild to severe refractory disease and is classified into various clinical phenotypes. Severe asthma is difficult to treat and frequently requires high doses of systemic glucocorticoids. In some cases, severe asthma even responds poorly to glucocorticoids. Several studies have suggested a central role of interleukin-17 (IL-17) in severe asthma. Indeed, high levels of IL-17 are found in induced sputum and bronchial biopsies obtained from severe asthmatics. IL-17 has also been described in multiple aspects of asthma pathogenesis. In this article therefore, we frame the topic of IL-17 effects in severe asthma by reviewing updated information from human studies and summarizing and discussing the implications of IL-17 in the regulation and control of neutrophilic airway inflammation, the induction of steroid resistance, and airway remodeling.

Key words: Interleukin-17, Severe asthma, Neutrophil inflammation, Steroid resistance, Airway remodeling

Qiannan Zhao, Wenwen Li, Xin Li, Caiqing Zhang. Role of interleukin-17 in severe asthma[J]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(02): 147-151.

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