Impact of intensity-modulated radiotherapy on myocardial damage in left-side breast cancer patients after breast-conserving surgery

doi:10.3877/cma.j.issn.1674-0785.2019.03.004

Abstract

Abstract:

Objective

To investigate the impact of intensity-modulated radiotherapy (IMRT) on myocardial damage in left-side breast cancer patients after breast-conserving surgery.

Methods

Forty-two left-side breast cancer patients treated by IMRT after breast-conserving surgery were selected at the Department of Radiotherapy of Peking University Cancer Hospital from June to December 2018. Their serum hypersensitivity cardiac troponin I (cTnI) levels were measured by chemiluminescence microparticle immunoassay before and after IMRT. The Kolmogorov-Smirnov normality test was used to compare the changes of serum hypersensitivity cTnI before and after IMRT. For data following a normal distribution, the paired-samples t-test was used, otherwise the non-parametric test was used. The χ² test was used for comparing the positive rate of hypersensitive cTnI before and after IMRT.

Results

Serum hypersensitivity cTnI values of the 42 patients increased significantly after IMRT compared to the values before treatment [(0.008±0.013) μg/L vs (0.006±0.010) μg/L, Z=-3.098, P=0.002], whereas the difference in the positive rates of serum hypersensitivity cTnI before and after IMRT was not statistically significant (0 vs 4.8%, χ²=4.000, P=0.261).

Conclusion

Serum hypersensitivity cTnI is sensitive to IMRT for left-side breast cancer patients after breast-conserving surgery, but significant myocardial damage may not occur under the limited dose.

Key words: Breast cancer, Breast conserving surgery, Serum hypersensitivity cardiac troponin I, Intensity-modulated radiotherapy

Wenshu Wang, Guobin Xu, Siyuan Zhang, Jian Tie. Impact of intensity-modulated radiotherapy on myocardial damage in left-side breast cancer patients after breast-conserving surgery[J]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(03): 175-178.

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Figures/Tables 3

References 17

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?	放疗前	放疗后	统计值	P值
超敏cTnI（μg/L，±s）	0.006±0.010	0.008±0.013	Z=-3.098	0.002
超敏cTnI阳性［例（%）］	0（0）	2（4.8%）	χ²=4.000	0.261

?	放疗前	放疗后	统计值	P值
超敏cTnI（μg/L，±s）	0.006±0.010	0.008±0.013	Z=-3.098	0.002
超敏cTnI阳性［例（%）］	0（0）	2（4.8%）	χ²=4.000	0.261

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