Progress in application of botulinum toxin in ophthalmology

doi:10.3877/cma.j.issn.1674-0785.2019.12.016

Abstract

Abstract:

Botulinum toxin is a neurotoxin protein produced by Clostridium botulinum. Its mechanism of action is to block the release of acetylcholine from the neuromuscular junction of the cholinergic nerve and block the conduction impulse. In ophthalmologic treatment, botulinum toxin has been routinely applied to the treatment of eye diseases such as blepharospasm, strabismus, wrinkles around the eyes, and upper eyelid contracture. This article reviews the progress in the application of botulinum toxin in ophthalmology.

Key words: Botulinum toxin, Ophthalmology, Blepharospasm

Jiamin Tang, Shu Liang, Jingjing Qian. Progress in application of botulinum toxin in ophthalmology[J]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(12): 952-954.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhlcyszz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0785.2019.12.016

https://zhlcyszz.cma-cmc.com.cn/EN/Y2019/V13/I12/952

References 22

1	Nigam PK, Nigam A. Botulinum toxin [J]. Indian J Dermatol, 2010, 55(1): 8-14.
2	Dressler D. Botulinum toxin for treatment of dystonia [J]. Eur J Neurol, 2010, 17(s1): 88-96.
3	Wabbels B, Jost WH, Roggenkämper P. Difficulties with differentiating botulinum toxin treatment effects in essential blepharospasm [J]. Journal of neural transmission, 2011, 118(6): 925-943.
4	焦永红,王乙迪,潘哲. A型肉毒毒素治疗眼睑痉挛的临床研究[J].国际眼科杂志, 2014, 14(7): 1350-1351.
5	陆秀兰,蔡春艳,涂惠芳. A型肉毒毒素不同注射位置治疗眼睑痉挛的疗效观察[J].国际眼科杂志, 2016, 16(12): 2351-2353.
6	Gunton KB, Wasserman BN, DeBenedictis C. Strabismus[J]. Primary Care: Clinics in Office Practice, 2015, 42(3): 393-407.
7	Rowe FJ, Noonan CP. Botulinum toxin for the treatment of strabismus [J]. Cochrane Database Syst Rev, 2017, 3: CD006499.
8	Issaho DC, de Souza Carvalho FR, Tabuse MKU, et al. The Use of Botulinum Toxin to Treat Infantile Esotropia: A Systematic Review With Meta-Analysis[J]. Investigative ophthalmology & visual science, 2017, 58(12): 5468-5476.
9	管怀进.眼科学[M]. 2版.北京:科学出版社, 2013: 95-99.
10	Messmer EM. The pathophysiology, diagnosis, and treatment of dry eye disease [J]. Deutsches Ärzteblatt International, 2015, 112(5): 71-81.
11	Valim V, Trevisani VFM, de Sousa JM, et al. Current approach to dry eye disease [J]. Clinical reviews in allergy & immunology, 2015, 49(3): 288-297.
12	Bukhari AA. Botulinum neurotoxin type A versus punctal plug insertion in the management of dry eye disease [J]. Oman journal of ophthalmology, 2014, 7(2): 61-65.
13	Victoria AC, Pino A. Botulinum toxin type a and its uses in dry eye disease [J]. Plastic and reconstructive surgery, 2012, 130(1): 209e-210e.
14	肖利华.甲状腺相关眼病的诊断和治疗[J].中国眼耳鼻喉科杂志, 2006, 6(3): 140-142.
15	钟思思,刘泽阳,吴旭昇.甲状腺相关眼病患者生活质量下降相关因素分析[J].国际眼科杂志, 2017, 17(2): 311-316.
16	曾广川,廖武,李瑜明.肉毒杆菌毒素A治疗特发性上睑退缩的临床观察[J]. 中国实用眼科杂志, 2005, 23(3): 315-316.
17	管怀进.眼科学[M]. 2版.北京:科学出版社, 2013: 79-80.
18	Knezevic T, Ivekovic R, Astalos JP, et al. Botulinum toxin A injection for primary and recurrent chalazia [J]. Graefe′s archive for clinical and experimental ophthalmology, 2009, 247(6): 789-794.
19	Capelle HH, Weigel R, Krauss JK. Bilateral pallidal stimulation for blepharospasm-oromandibular dystonia (Meige syndrome) [J].Neurology, 2003, 60(12): 2017-2018.
20	Mauriello JA. Blepharospasm, Meige syndronfie, and hemifacial Spasm Treatment with botulinunn toxin [J]. Neurology, 1985, 35(10): 1499-1500.
21	Polo CG, Sanz MFR, Izquierdo NB, et al. Blepharospasm and hemifacial spasm: long-term treatment with botulinum toxin [J]. Neurología (English Edition), 2013, 28(3): 131-136.
22	Iozzo I, Tengattini V, Antonucci VA. Multipoint and multilevel injection technique of botulinum toxin A in facial aesthetics [J]. Journal of cosmetic dermatology, 2014, 13(2): 135-142.

[1]	Haiyan Xu, Hui Li, Dongdong Xu, Ruxin Jiang, Youxin Chen. Effect of botulinum toxin type A injection on restrictive strabismus of thyroid associated ophthalmopathy under ultrasound monitoring [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2018, 15(11): 864-868.
[2]	Jiandi He, Guo Tian, Shanyu Yin, Ying Hu, Liyun Zhong, Tianan Jiang, Qiyu Zhao. Efficacy of botulinum toxin injection for regional pain by ultrasonography: a meta-analysis [J]. Chinese Journal of Critical Care Medicine(Electronic Edition), 2021, 14(06): 484-488.
[3]	Wenxu Dong, Guanglei Tong, Hong Li, Yunfei Cai, Ping Wang. Botulinum toxin type A combined with sling exercise training in treatment of spastic cerebral palsy and its effect on motor functions [J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2021, 17(02): 190-197.
[4]	Yerong Jiang, Ran Huo. Clinical progress of type A botulinum toxin [J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2017, 12(04): 298-302.
[5]	Yang Lu, Zhenzhen Zhang, Xia Zhang, Xuedi Zhang, Chun Wang, Zhijie Yang, Xiaofeng Bai. Efficacy of botulinum toxin type A combined with ropivacaine in the treatment of trigeminal neuralgia [J]. Chinese Journal of Stomatological Research(Electronic Edition), 2020, 14(01): 24-28.
[6]	Fuxin Tang, Ning Ma, Taicheng Zhou, Shuang Chen. Application of botulinum toxin type A in complex abdominal wall defects [J]. Chinese Archives of General Surgery(Electronic Edition), 2019, 13(04): 324-326.
[7]	Dandan Wang, Xiuhua Wan. The analysis of Youth Science Fund Projects funded pattern of National Natural Science Foundation in ophthalmology [J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2020, 10(04): 245-250.
[8]	Dandan Wang, Lihua Du. The analysis of General Projects funded pattern of National Natural Science Foundation general projects in ophthalmology [J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2020, 10(04): 239-244.
[9]	Han Su, Jing Fu, Xiao Wu, Ali Sun, Bowen Zhao, Jie Hong. Comparison of botulinum toxin type A with surgery in the treatment of concomitant strabismus in children [J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2020, 10(02): 83-89.
[10]	Li Zhang, Jie Xu, Kai Cao, Hanruo Liu, Yunxiao Sun, Jianjun Li, Ningli Wang. The role of teleophthalmology consulting in improving glaucoma diagnosis in population [J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2019, 09(04): 206-211.
[11]	Ruiqi Pang, Hanruo Liu, Ningli Wang. Analysis on the characteristics of ophthalmology papers published in highly impact journals and the significance of deep learning algorithm in ophthalmology research [J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2019, 09(02): 65-70.
[12]	Zhangqing Feng, Junhong Li. Pay attention to the choice of operation time, operation method and treatment of complications after cataract surgery in children [J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2019, 09(01): 1-6.
[13]	Zhenyu Wang, Chen Huang, Xuemin Li. Pay attention to the application of genetic mutation site pathogenicity prediction software in ophthalmology [J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2018, 08(06): 241-248.
[14]	Ting Li, Li Yin. To investigate the efficacy of botulinum orbicularis toxin type A combined with orbicularis oculi muscle, orbicularis oculi muscle and frontalis muscle injection in the treatment of benign idiopathic blepharospasm [J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2017, 07(04): 165-170.
[15]	Sisong Wang, Ji Ren, Jianping Xiong, Hongwei Zheng, Changping Chen, Huadong Sun, Yongjun Chen, Huan Zhang, Wen Feng, Haipeng Pan. Analysis of botulinum toxin type A in the treatment of chronic migraine: a report of 47 cases [J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2021, 11(01): 9-13.

Please choose a citation manager

Content to export