Clinical and pathological characteristics of patients with pregnancy-associated breast cancer: retrospective analysis of 13 cases

doi:10.3877/cma.j.issn.1674-0785.2020.05.002

Abstract

Abstract:

Objective

To investigate the clinical and pathological characteristics of pregnancy-associated breast cancer (PABC) and analyze its prognostic factors .

Methods

We retrospectively analyzed the clinicopathologic features of patients with PABC treated at Peking University First Hospital between January 2008 and January 2019.

Results

Of all 4010 patients included in this study, 13 (0.32%) were diagnosed with PABC. According to American Joint Committee on Cancer staging system, 1 case was clinical stage I, 6 were stage II, 4 were stage Ⅲ, and 2 were stage Ⅳ; 3 cases were prognostic stage I, 4 were stage II, 4 were stage III, and 2 were stage Ⅳ. As for molecular subtype, 7 cases were luminal B, 3 were HER-2 positive, and 3 were triple-negative breast cancer. Most patients had clinicopathological factors that are related to a poor prognosis. The median follow-up duration was 27 months, 3-year overall survival rate was 79.1%, and 3-year disease-free survival rate was 88.9%.

Conclusion

PABC is a rare disease with advanced stage and poor prognosis. As the one-child policy is changing in China, the incidence of PABC tends to increase. Therefore, it is extremely urgent to standardize the treatment of PABC.

Key words: Breast neoplasms, Pregnancy, Prognosis, Neoplasm staging

Qian Wu, Ling Xin, Qian Liu, Hong Zhang, Shuang Zhang, Ling Xu, Jingming Ye, Xuening Duan, Yinhua Liu. Clinical and pathological characteristics of patients with pregnancy-associated breast cancer: retrospective analysis of 13 cases[J]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(05): 326-331.

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References 26

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项目		确诊时间		合计
项目		2008年1月至2016年12月	2017年1月至2019年1月	合计
例数		6（46.2%）	7（53.8%）	13
中位年龄（范围，岁）		33（27~38）	32（25~38）	33（25~38）
发病胎次（例）		?	?	?
?	一胎	3	1	4
?	二胎	3	6	9
确诊时期（例）		?	?	?
?	妊娠期	2	2	4
?	哺乳期	4	5	9
临床分期（例）		?	?	?
?	I期	1	0	1
?	II期	3	3	6
?	III期	2	2	4
?	Ⅳ期	0	2	2
预后分期（例）		?	?	?
?	I期	2	1	3
?	Ⅱ期	2	2	4
?	Ⅲ期	2	2	4
?	Ⅳ期	0	2	2
组织学分级（例）		?	?	?
?	G1	0	1	1
?	G2	4	4	8
?	G3	2	2	4
分子分型（例）		?	?	?
?	Luminal A型	0	0	0
?	Luminal B型	4	3	7
?	HER-2阳性型	1	2	3
?	三阴型	1	2	3
早期乳腺癌危险度分层（例）		?	?	?
?	低度危险	0	0	0
?	中度危险	3	2	5
?	高度危险	3	3	6

项目		确诊时间		合计
项目		2008年1月至2016年12月	2017年1月至2019年1月	合计
例数		6（46.2%）	7（53.8%）	13
中位年龄（范围，岁）		33（27~38）	32（25~38）	33（25~38）
发病胎次（例）		?	?	?
?	一胎	3	1	4
?	二胎	3	6	9
确诊时期（例）		?	?	?
?	妊娠期	2	2	4
?	哺乳期	4	5	9
临床分期（例）		?	?	?
?	I期	1	0	1
?	II期	3	3	6
?	III期	2	2	4
?	Ⅳ期	0	2	2
预后分期（例）		?	?	?
?	I期	2	1	3
?	Ⅱ期	2	2	4
?	Ⅲ期	2	2	4
?	Ⅳ期	0	2	2
组织学分级（例）		?	?	?
?	G1	0	1	1
?	G2	4	4	8
?	G3	2	2	4
分子分型（例）		?	?	?
?	Luminal A型	0	0	0
?	Luminal B型	4	3	7
?	HER-2阳性型	1	2	3
?	三阴型	1	2	3
早期乳腺癌危险度分层（例）		?	?	?
?	低度危险	0	0	0
?	中度危险	3	2	5
?	高度危险	3	3	6

项目		确诊时间		合计
项目		2008年1月至2016年12月	2017年1月至2019年1月	合计
早期乳腺癌		6	5	11
新辅助化疗		?	?	?
?	是	5	5	10
?	否	1	0	1
新辅助化疗疗效评价		?	?	?
?	CR及PR	4	4	8
?	SD	1	1	2
?	PD	0	0	0
手术方式		?	?	?
?	单纯切除	5	2	7
?	保乳手术	1	1	2
?	单纯切除＋一期重建	0	2	2
Miller-Payne分级		?	?	?
?	G1	0	2	2
?	G2	0	0	0
?	G3	3	2	5
?	G4	1	0	1
?	G5	1	1	2

项目		确诊时间		合计
项目		2008年1月至2016年12月	2017年1月至2019年1月	合计
早期乳腺癌		6	5	11
新辅助化疗		?	?	?
?	是	5	5	10
?	否	1	0	1
新辅助化疗疗效评价		?	?	?
?	CR及PR	4	4	8
?	SD	1	1	2
?	PD	0	0	0
手术方式		?	?	?
?	单纯切除	5	2	7
?	保乳手术	1	1	2
?	单纯切除＋一期重建	0	2	2
Miller-Payne分级		?	?	?
?	G1	0	2	2
?	G2	0	0	0
?	G3	3	2	5
?	G4	1	0	1
?	G5	1	1	2

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