Clinicopathologic characteristics of inflammatory breast cancer cases: analysis of 25 cases

doi:10.3877/cma.j.issn.1674-0785.2020.05.003

Abstract

Abstract:

Objective

To investigate the clinicopathologic features and prognostic factors of inflammatory breast cancer (IBC).

Methods

We retrospectively analyzed the clinicopathologic characteristics and outcomes of patients with IBC diagnosed at Peking University First Hospital from January 2012 to December 2018.

Results

A total of 25 patients with IBC were included, accounting for 0.89% (25/2811) of newly diagnosed breast cancer cases at our center. All patients had complete clinicopathologic data and follow-up results. Seventeen (68%) patients had stage Ⅲ IBC, and eight (32%) had stage Ⅳ disease. The numbers of patients with luminal B (HER-2 negative), HER-2 positive, and triple-negative breast cancer were 9 (36%), 5 (20%), and 11 (44%), respectively. Nineteen patients underwent surgery, 94.7% of whom achieved local R0 resection. The median survival time was 18.2 months. The 2-year overall survival rates of patients with prognostic stage ⅢB, stage ⅢC, and stage Ⅳ disease were 72.9%, 66.7%, and 15.6%, respectively; there was a significant difference among them (χ²=13.247, P<0.001).

Conclusion

IBC is a rare, aggressive disease with advanced stage and poor disease outcome. Local R0 resection can be achieved in more than 90% of patients after neoadjuvant therapy.

Key words: Inflammatory breast cancer, Molecular subtype, Prognosis

Wei Wang, Ling Xin, Hong Zhang, Shuang Zhang, Ling Xu, Qian Liu, Jingming Ye, Yinhua Liu. Clinicopathologic characteristics of inflammatory breast cancer cases: analysis of 25 cases[J]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(05): 332-336.

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Figures/Tables 2

References 21

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临床特征		例数（%）
年龄（岁）		?
?	<35	5（20）
?	≥35	20（80）
月经状态		?
?	绝经前	18（72）
?	绝经后	7（28）
分子分型^a		?
?	Luminal B型（HER-2阴性）	9（36）
?	HER-2阳性型	5（20）
?	三阴型	11（44）
组织学分级		?
?	1	1（4）
?	2	7（28）
?	3	17（68）
临床分期^b		?
?	ⅢB	15（60）
?	ⅢC	2（8）
?	Ⅳ	8（32）
预后分期^b		?
?	ⅢB	11（44）
?	ⅢC	6（24）
?	Ⅳ	8（32）
Ki-67		?
?	<15%	0
?	15%~30%	7（28）
?	>30%	18（72）
脉管癌栓		?
?	有	8（32）
?	无	17（68）

临床特征		例数（%）
年龄（岁）		?
?	<35	5（20）
?	≥35	20（80）
月经状态		?
?	绝经前	18（72）
?	绝经后	7（28）
分子分型^a		?
?	Luminal B型（HER-2阴性）	9（36）
?	HER-2阳性型	5（20）
?	三阴型	11（44）
组织学分级		?
?	1	1（4）
?	2	7（28）
?	3	17（68）
临床分期^b		?
?	ⅢB	15（60）
?	ⅢC	2（8）
?	Ⅳ	8（32）
预后分期^b		?
?	ⅢB	11（44）
?	ⅢC	6（24）
?	Ⅳ	8（32）
Ki-67		?
?	<15%	0
?	15%~30%	7（28）
?	>30%	18（72）
脉管癌栓		?
?	有	8（32）
?	无	17（68）

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