Progress in understanding the role of tumor stem cells in drug resistance and metastasis in colorectal cancer

doi:10.3877/cma.j.issn.1674-0785.2020.09.013

Abstract

Abstract:

Colorectal cancer is one of the leading causes of cancer-related deaths worldwide. The vast majority of colorectal cancer patients die of recurrence and metastasis after surgery. More and more evidence has revealed the existence of cancer stem cells (CSC) and its role in cancer resistance and metastasis. Tumor stem cells are a small fraction of tumor cells that can trigger tumor formation and make the tumor heterogeneous. In addition, tumor stem cells are resistant to a variety of cytotoxic factors and thus result in drug resistance and metastasis in patients with colorectal cancer after surgery.

Key words: Colorectal cancer, Cancer stem cell, Resistance, Metastasis

Zhihao Yin, Zhiliang Zhang, Jiawu Xiao, Qi Fan, Dehai Xiong. Progress in understanding the role of tumor stem cells in drug resistance and metastasis in colorectal cancer[J]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(09): 730-734.

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