Progress in research of intestinal mucosal barrier function and its dysfunction mechanisms

doi:10.3877/cma.j.issn.1674-0785.2020.09.014

Abstract

Abstract:

The intestinal mucosal barrier is composed of intestinal epithelial cells and extracellular components, which has the characteristics of complex structure and diverse functions. In the form of dynamic changes, the intestinal mucosa barrier selectively absorbs water and nutrients, prevents intestinal bacterial translocation, and has intestinal immune function in the process of digestion, so as to help the body maintain the integrity of the intestinal tract and immune homeostasis. The causes of intestinal mucosal barrier dysfunction, such as chronic inflammation, dysbacteriosis, and changes in environmental factors, can independently or collaboratively cause biochemical cascade reactions, leading to the occurrence of chronic inflammation and a variety of intestinal diseases, such as inflammatory bowel disease, irritable bowel syndrome, colonic cancer, and some extraintestinal diseases (such as chronic nonalcoholic liver disease, type I diabetes, and obesity). It is of great significance to understand the mechanism of intestinal mucosal barrier dysfunction for the study of intestinal diseases or extraintestinal related diseases.

Key words: Intestinal mucosa, Intestinal diseases, Review, Intestinal mucosal barrier

Pengfei Niu, Yanzhao Wang, Qingmin Zeng, Fuming Lei. Progress in research of intestinal mucosal barrier function and its dysfunction mechanisms[J]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(09): 735-739.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhlcyszz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0785.2020.09.014

https://zhlcyszz.cma-cmc.com.cn/EN/Y2020/V14/I09/735

References 58

1	Turner JR. Intestinal mucosal barrier function in health and disease [J]. Nat Rev Immunol, 2009, 9(11): 799-809.
2	Vancamelbeke M, Vermeire S. The intestinal barrier: a fundamental role in health and disease [J]. Expert Rev Gastroenterol Hepatol, 2017, 11(9): 821-834.
3	Nalle SC, Turner JR. Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease [J]. Mucosal Immunol, 2015, 8(4): 720-30.
4	Nagpal R, Yadav H. Bacterial Translocation from the gut to the distant organs: an overview [J]. Ann Nutr Metab, 2017, 71 Suppl 1: 11-16.
5	Mowat AM. Anatomical basis of tolerance and immunity to intestinal antigens [J]. Nat Rev Immunol, 2003, 3(4): 331-341.
6	黎介寿. 肠衰竭—概念、营养支持与肠粘膜屏障维护 [J]. 中国临床营养杂志, 2004, 12(3): 155-8.
7	Kurashima Y, Kiyono H. Mucosal ecological network of epithelium and immune cells for gut homeostasis and tissue healing [J]. Annu Rev Immunol, 2017, 35: 119-147.
8	Groschwitz KR, Hogan SP. Intestinal barrier function: molecular regulation and disease pathogenesis [J]. J Allergy Clin Immunol, 2009, 124(1): 3-20; quiz 1-2.
9	Edelblum KL, Turner JR. The tight junction in inflammatory disease: communication breakdown [J]. Curr Opin Pharmacol, 2009, 9(6): 715-720. URL
10	Fuladi S, Jannat RW, Shen L, et al. Computational Modeling of Claudin Structure and Function [J]. Int J Mol Sci, 2020, 21(3): 742.
11	Jin Y, Ibrahim D, Magness ST, et al. Knockout of ClC-2 reveals critical functions of adherens junctions in colonic homeostasis and tumorigenicity [J]. Am J Physiol Gastrointest Liver Physiol, 2018, 315(6): G966-G979.
12	Salvo Romero E, Alonso Cotoner C, Pardo Camacho C, et al. The intestinal barrier function and its involvement in digestive disease [J]. Rev Esp Enferm Dig, 2015, 107(11): 686-696.
13	Kojima T, Murata M, Go M, et al. Connexins induce and maintain tight junctions in epithelial cells [J]. J Membr Biol, 2007, 217(1-3): 13-19.
14	Johansson MEV, Larsson JMH, Hansson GC. The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions [J]. Proc Natl Acad Sci USA, 2011, 108 (Suppl 1): 4659-4665.
15	Pelaseyed T, Bergstrom JH, Gustafsson JK, et al. The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system [J]. Immunol Rev, 2014, 260(1): 8-20.
16	Muniz LR, Knosp C, Yeretssian G. Intestinal antimicrobial peptides during homeostasis, infection, and disease [J]. Front Immunol, 2012, 3: 310.
17	Chairatana P, Nolan EM. Defensins, lectins, mucins, and secretory immunoglobulin A: microbe-binding biomolecules that contribute to mucosal immunity in the human gut [J]. Crit Rev Biochem Mol Biol, 2017, 52(1): 45-56.
18	Cerutti A, Rescigno M. The biology of intestinal immunoglobulin A responses [J]. Immunity, 2008, 28(6): 740-750. URL
19	Corr SC, Gahan CC, Hill C. M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis [J]. FEMS Immunol Med Microbiol, 2008, 52(1): 2-12.
20	Gill N, Wlodarska M, Finlay BB. Roadblocks in the gut: barriers to enteric infection [J]. Cell Microbiol, 2011, 13(5): 660-669. URL
21	Castoldi A, Favero de Aguiar C, Moraes-Vieira PM, et al. They must hold tight: junction proteins, microbiota and immunity in intestinal mucosa [J]. Curr Protein Pept Sci, 2015, 16(7): 655-671.
22	Takiishi T, Fenero CIM, Câmara NOS. Intestinal barrier and gut microbiota: Shaping our immune responses throughout life [J]. Tissue Barriers, 2017, 5(4): e1373208.
23	Schroeder BO. Fight them or feed them: how the intestinal mucus layer manages the gut microbiota [J]. Gastroenterol Rep (Oxf), 2019, 7(1): 3-12.
24	Haussner F, Chakraborty S, Halbgebauer R, et al. Challenge to the Intestinal Mucosa During Sepsis [J]. Front Immunol, 2019, 10: 891.
25	Wells JM, Brummer RJ, Derrien M, et al. Homeostasis of the gut barrier and potential biomarkers [J]. Am J Physiol Gastrointest Liver Physiol, 2017, 312(3): G171-G193.
26	Kanoore edul VS, Dubin A, Ince C. The microcirculation as a therapeutic target in the treatment of sepsis and shock [J]. Semin Respir Crit Care Med, 2011, 32(5): 558-568.
27	Wang L, Bastarache JA, Ware LB. The coagulation cascade in sepsis [J]. Curr Pharm Des, 2008, 14(19): 1860-1869.
28	Gustot T. Multiple organ failure in sepsis: prognosis and role of systemic inflammatory response [J]. Curr Opin Crit Care, 2011, 17(2): 153-159. URL
29	Defazio J, Fleming ID, Shakhsheer B, et al. The opposing forces of the intestinal microbiome and the emerging pathobiome [J]. Surg Clin North Am, 2014, 94(6): 1151-1161.
30	Jiang LY, Zhang M, Zhou TE, et al. Changes of the immunological barrier of intestinal mucosa in rats with sepsis [J]. World J Emerg Med, 2010, 1(2): 138-143.
31	Chang RM, Wen LQ, Chang JX, et al. Repair of damaged intestinal mucosa in a mouse model of sepsis [J]. World J Emerg Med, 2013, 4(3): 223-228.
32	Farooq PD, Urrunaga NH, Tang DM, et al. Pseudomembranous colitis [J]. Dis Mon, 2015, 61(5): 181-206.
33	Rodriguez C, Taminiau B, Van broeck J, et al. Clostridium difficile infection and intestinal microbiota interactions [J]. Microb Pathog, 2015, 89: 201-209.
34	Fachi JL, Felipe JS, Pral LP, et al. Butyrate protects mice from clostridium difficile-induced colitis through an HIF-1-dependent mechanism [J]. Cell Rep, 2019, 27(3): 750-761, e7.
35	Buffie CG, Bucci V, Stein RR, et al. Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile [J]. Nature, 2015, 517(7533): 205-208.
36	Schubert AM, Rogers MAM, Ring C, et al. Microbiome data distinguish patients with Clostridium difficile infection and non-C. difficile-associated diarrhea from healthy controls [J]. mBio, 2014, 5(3): e01021-14.
37	Van Nood E, Vrieze A, Nieuwdorp M, et al. Duodenal infusion of donor feces for recurrent Clostridium difficile [J]. N Engl J Med, 2013, 368(5): 407-415.
38	Podolsky DK. Inflammatory bowel disease (1) [J]. N Engl J Med, 1991, 325(13): 928-037.
39	Ventham NT, Kennedy NA, Nimmo ER, et al. Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics [J]. Gastroenterology, 2013, 145(2): 293-308. URL
40	Grill JI, Neumann J, Hiltwein F, et al. Intestinal E-cadherin deficiency aggravates dextran sodium sulfate-induced colitis [J]. Dig Dis Sci, 2015, 60(4): 895-902.
41	Tanaka H, Takechi M, Kiyonari H, et al. Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice [J]. Gut, 2015, 64(10): 1529-1538.
42	Laukoetter MG, Nava P, Lee WY, et al. JAM-A regulates permeability and inflammation in the intestine in vivo [J]. J Exp Med, 2007, 204(13): 3067-3076.
43	Vetrano S, Rescigno M, Cera MR, et al. Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease [J]. Gastroenterology, 2008, 135(1): 173-184.
44	Wang F, Graham WV, Wang Y, et al. Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression [J]. Am J Pathol, 2005, 166(2): 409-419.
45	Suenaert P, Bulteel V, Lemmens L, et al. Anti-tumor necrosis factor treatment restores the gut barrier in Crohn′s disease [J]. Am J Gastroenterol, 2002, 97(8): 2000-2004.
46	Allais L, Kerckhof FM, Verschuere S, et al. Chronic cigarette smoke exposure induces microbial and inflammatory shifts and mucin changes in the murine gut [J]. Environ Microbiol, 2016, 18(5): 1352-1363.
47	Fricker M, Goggins BJ, Mateer S, et al. Chronic cigarette smoke exposure induces systemic hypoxia that drives intestinal dysfunction [J]. JCI Insight, 2018, 3(3): pii 94040.
48	Bull-Otterson L, Feng W, Kirpich I, et al. Metagenomic analyses of alcohol induced pathogenic alterations in the intestinal microbiome and the effect of Lactobacillus rhamnosus GG treatment [J]. PLoS One, 2013, 8(1): e53028.
49	Fleming S, Toratani S, Shea-Donohue T, et al. Pro- and anti-inflammatory gene expression in the murine small intestine and liver after chronic exposure to alcohol [J]. Alcohol Clin Exp Res, 2001, 25(4): 579-589.
50	Malaguarnera G, Giordano M, Nunnari G, et al. Gut microbiota in alcoholic liver disease: pathogenetic role and therapeutic perspectives [J]. World J Gastroenterol, 2014, 20(44): 16639-16648.
51	Wang DQ, Carey MC. Therapeutic uses of animal biles in traditional Chinese medicine: an ethnopharmacological, biophysical chemical and medicinal review [J]. World J Gastroenterol, 2014, 20(29): 9952-9975.
52	Hegyi P, Maleth J, Walters JR, et al. Guts and gall: bile acids in regulation of intestinal epithelial function in health and disease [J]. Physiol Rev, 2018, 98(4): 1983-2023.
53	Merchant NB, Rogers CM, Trivedi B, et al. Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells [J]. Surgery, 2005, 138(3): 415-421.
54	Raimondi F, Santoro P, Barone MV, et al. Bile acids modulate tight junction structure and barrier function of Caco-2 monolayers via EGFR activation [J]. Am J Physiol Gastrointest Liver Physiol, 2008, 294(4): G906-G913.
55	König J, Wells J, Cani PD, et al. Human Intestinal Barrier Function in Health and Disease [J]. Clin Transl Gastroenterol, 2016, 7(10): e196.
56	Vanuytsel T, Van Wanrooy S, Vanheel H, et al. Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism [J]. Gut, 2014, 63(8): 1293-1299. URL
57	Rodiño-Janeiro BK, Alonso-Cotoner C, Pigrau M, et al. Role of corticotropin-releasing factor in gastrointestinal permeability [J]. J Neurogastroenterol Motil, 2015, 21(1): 33-50.
58	Stevens BR, Goel R, Seungbum K, et al. Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression [J]. Gut, 2018, 67(8): 1555-1557.

[1]	Wen Lin, Yuxuan Wang, Jiayue Xu, Jinqun Wang, Ruina Wang, Dongyuan He, Pei Fan. Research progress of artificial joint replacement registry [J]. Chinese Journal of Joint Surgery(Electronic Edition), 2023, 17(06): 834-841.
[2]	Yangwenxiang Wei, Haoran Huang, Yuhao Liu, Zhenqiu Chen, Haibin Wang, Chi Zhou. Outlooks and challenges in cell therapy of osteonecrosis of femoral head [J]. Chinese Journal of Joint Surgery(Electronic Edition), 2023, 17(05): 694-700.
[3]	Rungong Yang. Emphasize the major medical needs of the national army and promote the rapid development of wound repair department [J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2023, 18(03): 191-196.
[4]	Guangyu Yang, Lu Wang, Yu Wang, Chi Zhang, Jun Zeng, Hua Jiang, Mingwei Sun. Effect of intravenous omega-3 fatty acids on outcome of patients with sepsis: a systematic review and meta-analysis [J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2023, 18(02): 148-156.
[5]	Huachan Lin, Saijuan Lin, Minxue Chen. Anesthetic effect of transversalis fascia block in elderly patients with indirect hernia and its influence on intestinal mucosal barrier function [J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2023, 17(04): 454-457.
[6]	Fengshang Zhu, Ling She, Yongnian Ding, Changqing Yang. Maintaining vigilance in the differential diagnosis of inflammatory bowel disease and rare bowel disorders [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(05): 273-276.
[7]	Chunhua Qiu, Zhihong Zhang. Clinical diagnosis and examination strategy for small intestinal diseases: analysis of 1108 cases [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(9): 948-954.
[8]	Hui Fang, Fei Li, Fan Zhang, Qiang Wei, Qiangpu Chen. Effect of exogenous leptin on intestinal mucosal proliferation in rats with obstructive jaundice [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(05): 575-580.
[9]	Xuefen Chen, Jingmin Deng. Literature review of 179 cases of primary pulmonary lymphoepithelioma-like carcinoma in the last 30 years [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(05): 551-556.
[10]	Fei Kong, Fabing Tang, Qiong Wei, Shanlin Fan, Wenzhen Yuan. Surgical treamtent of giant gastrointestinal mesenchymal tumor after neoadjuvant therapy: a case report and review of the literature [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(03): 360-363.
[11]	Yadong Shi, Jianping Gu. Progress in diagnosis and treatment for silent pulmonary embolism [J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2023, 11(02): 155-158.
[12]	Dan Zhang, Xinsheng Yan, Litao Zhang, Zhenlu Zhang, Dong Wang. Using quality tools to reduce the review rate of thalassemia genetic test [J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2023, 11(02): 79-83.
[13]	Jing Chen, Yanyan Lu, Yaodong Xu, Yingcai Ma. Research progress of linked color imaging technology in intestinal diseases [J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2023, 10(03): 195-199.
[14]	Qing Wang, Guanfeng Wang, Xing Chen. The value of Hill classification of gastroesophageal flap valve in gastroesophageal reflux disease [J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2023, 10(02): 125-130.
[15]	Sujuan Sang, Yingying Wang, Linan Li, Xiaobing Liu, Yanni Lei, Yanshuang Cheng. Research progress of gastric tube aspirate pH test method for gastric tube localization [J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2023, 10(02): 131-135.

Please choose a citation manager

Content to export