Autophagy is a conservative catabolic process in which solute components or organelles are degraded and recycled via lysosomal dependent pathways. It is responsible for the degradation of long-lived proteins, protein aggregates, and damaged organelles to maintain cell homeostasis. Thus, abnormalities in autophagy are associated with many diseases, including Alzheimer's disease, Parkinson's disease, and cancer. According to current views, autophagy appears to act as a tumor inhibitor in the early stages of cancer formation, but in the later stages, it promotes tumor growth and spread. MicroRNAs (miRNAs) are endogenous non-coding small RNAs that regulate gene expression by silencing mRNA targets. MiRNA imbalance shows great regulatory potential in somatic cell development, hematopoiesis, immunity, cell proliferation and death, and autophagy. In recent years, a large number of studies have shown that miRNAs can regulate autophagy by regulating the expression of targeted genes, thus contributing to the formation and progression of cancer. In this review, we briefly discuss the role of miRNAs in regulation of autophagy in cancer.