Advances in the role of 12/15-LOX in myocardial ischemia- reperfusion injury

doi:10.3877/cma.j.issn.1674-0785.2021.01.013

Abstract

Abstract:

12/15-lipoxygenase (12/15-lipoxygenase, 12/15-LOX) is a member of the lipoxygenase (LOXs, lipoxygenases) family. It can be involved in catalyzing the oxidation of various fatty acids to produce a variety of lipid components, which is of great significance in biology. At the same time, 12/15-LOX plays an important role in the pathophysiological process of various immune and inflammatory diseases. 12/15-LOX and its related products are widely distributed in tissues and play an important role in the process of diabetes, liver, cardiovascular and cerebrovascular diseases. Myocardial ischemia-reperfusion injury is a kind of severe myocardial injury, in which inflammatory reaction, oxidative stress, apoptosis and other mechanisms are involved. In this paper, the role of 12/15-LOX in myocardial ischemia-reperfusion injury is reviewed.

Key words: Myocardial ischemia-reperfusion, 12/15-lipoxygenase, Ferroptosis

Chunyu Wu, Min Pan, Qingquan Zhang. Advances in the role of 12/15-LOX in myocardial ischemia- reperfusion injury[J]. Chinese Journal of Clinicians(Electronic Edition), 2021, 15(01): 65-71.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhlcyszz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0785.2021.01.013

https://zhlcyszz.cma-cmc.com.cn/EN/Y2021/V15/I01/65

References 63

1	Anderson JL, Morrow DA. Acute myocardial infarction [J]. N Engl J Med, 2017, 376(21): 2053-2064.
2	Armstrong SC. Protein kinase activation and myocardial ischemia/reperfusion injury [J]. Cardiovasc Res, 2004, 61(3): 427-436.
3	胡盛寿, 高润霖, 刘力生, 等. 《中国心血管病报告2018》概要 [J]. 中国循环杂志, 2019, 34(3): 209-220.
4	Morishima I, Sone T, Okumura K, et al. Angiographic no-reflow phenomenon as a predictor of adverse long-term outcome in patients treated with percutaneous transluminal coronary angioplasty for first acute myocardial infarction [J]. J Am Coll Cardiol, 2000, 36(4): 1202-1209.
5	Guadall A, Orriols M, Alcudia JF, et al. Hypoxia-induced ROS signaling is required for LOX up-regulation in endothelial cells [J]. Front Biosci (Elite Ed), 2011, 3: 955-967.
6	Van Leyen K, Kim HY, Lee SR, et al. Baicalein and 12/15-lipoxygenase in the ischemic brain [J]. Stroke, 2006, 37(12): 3014-3018.
7	Kain V, Ingle KA, Kabarowski J, et al. Genetic deletion of 12/15 lipoxygenase promotes effective resolution of inflammation following myocardial infarction [J]. J Mol Cell Cardiol, 2018, 118: 70-80.
8	Song L, Yang H, Wang HX, et al. Inhibition of 12/15 lipoxygenase by baicalein reduces myocardialischemia/reperfusioninjury via modulation of multiple signaling pathways [J]. Apoptosis, 2014, 19(4):567-580.
9	Funk CD, Chen XS, Johnson EN, et al. Lipoxygenase genes and their targeted disruption [J]. Prostaglandins Other Lipid Mediat, 2002, 68-69: 303-312.
10	Ivanov I, Kuhn H, Heydeck D. Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15) [J]. Gene, 2015, 573(1): 1-32.
11	谭震, 厉小梅. 12/15-脂氧合酶对骨质疏松的影响 [J]. 中华骨质疏松和骨矿盐疾病杂志, 2013, 6(3): 89-92.
12	Kayama Y, Minamino T, Toko H, et al. Cardiac 12/15 lipoxygenase-induced inflammation is involved in heart failure [J]. J Exp Med, 2009, 206(7):1565-1574.
13	Reilly KB, Srinivasan S, Hatley ME, et al. 12/15-Lipoxygenase activity mediates inflammatory monocyte/endothelial interactions and atherosclerosis in vivo [J]. J Biol Chem, 2004, 279(10): 9440-9450.
14	Suzuki H, Kayama Y, Sakamoto M, et al. Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress areinvolved in the development of diabetic cardiomyopathy [J]. Diabetes, 2015, 64(2): 618-630.
15	Zhao L, Funk CD. Lipoxygenase pathways in atherogenesis [J]. Trends Cardiovasc Med, 2004, 14(5): 191-195.
16	Sears DD, Miles PD, Chapman J, et al. 12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice [J]. PLoS One, 2009, 4(9): e7250.
17	Wen Y, Gu J, Chakrabarti SK, et al. The role of 12/15-lipoxygenase in the expression of interleukin-6 and tumor necrosis factor-alpha in macrophages [J]. Endocrinology, 2007, 148(3): 1313-1322.
18	Zhao L, Cuff CA, Moss E, et al. Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia [J]. J Biol Chem, 2002, 277(38): 35350-35356.
19	Chan MM, Moore AR. Resolution of inflammation in murine autoimmune arthritis is disrupted by cyclooxygenase-2 inhibition and restored by prostaglandin E2-mediated lipoxin A4 production [J]. J Immunol, 2010, 184(11): 6418-6426.
20	Lindley AR, Crapster-Pregont M, Liu Y, et al. 12/15-lipoxygenase is an interleukin-13 and interferon-γ counterregulated-mediator of allergic airway inflammation [J]. Mediators Inflamm, 2010, 2010: 727305.
21	Kalogeris T, Baines CP, Krenz M, et al. Ischemia/reperfusion [J]. Compr Physiol, 2016, 7(1): 113-170.
22	Han J, Sun L, Xu Y, et al. Activation of PPARγ by 12/15-lipoxygenase during cerebral ischemia-reperfusion injury [J]. Int J Mol Med, 2015, 35(1): 195-201.
23	Czapski GA, Czubowicz K, Strosznajder RP. Evaluation of the antioxidative properties of lipoxygenase inhibitors [J]. Pharmacol Rep, 2012, 64(5): 1179-1188.
24	Praticò D, Zhukareva V, Yao Y, et al. 12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress [J]. Am J Pathol, 2004, 164(5): 1655-1662.
25	Anning PB, Coles B, Bermudez-Fajardo A, et al. Elevated endothelial nitric oxide bioactivity and resistance to angiotensin-dependent hypertension in 12/15-lipoxygenase knockout mice [J]. Am J Pathol, 2005, 166(3): 653-662.
26	DelliPizzi A, Guan H, Tong X, et al. Lipoxygenase-dependent mechanisms in hypertension [J]. Clin Exp Hypertens, 2000, 22(2): 181-192.
27	Li Q, Li QQ, Jia JN, et al. Baicalein exerts neuroprotective effects in FeCl3-induced posttraumatic epileptic seizures via suppressing ferroptosis [J]. Front Pharmacol, 2019, 10: 638.
28	Del Re DP, Amgalan D, Linkermann A, et al. Fundamental mechanisms of regulated cell death and implications for heart disease [J]. Physiol Rev, 2019, 99(4): 1765-1817.
29	Sakamoto M, Minamino T, Toko H, et al. Upregulation of heat shock transcription factor 1 plays a critical role in adaptive cardiac hypertrophy [J]. Circ Res, 2006, 99(12): 1411-1418.
30	Sano M, Minamino T, Toko H, et al. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload [J]. Nature, 2007, 446(7134): 444-448.
31	Toko H, Takahashi H, Kayama Y, et al. Ca2+/calmodulin-dependent kinase IIdelta causes heart failure by accumulation of p53 in dilated cardiomyopathy [J]. Circulation, 2010, 122(9): 891-899.
32	Natarajan R, Yang DC, Lanting L, et al. Key role of P38 mitogen-activated protein kinase and the lipoxygenase pathway in angiotensin II actions in H295R adrenocortical cells [J]. Endocrine, 2002, 18(3): 295-301.
33	Natarajan R, Nadler JL. Lipid inflammatory mediators in diabetic vascular disease [J]. Arterioscler Thromb Vasc Biol, 2004, 24(9): 1542-1548.
34	Taylor AM, Hanchett R, Natarajan R, et al. The effects of leukocyte-type 12/15-lipoxygenase on Id3-mediated vascular smooth muscle cell growth [J]. Arterioscler Thromb Vasc Biol, 2005, 25(10): 2069-2074.
35	Zhang Y, Wang Y, Xu J, et al. Melatonin attenuates myocardial ischemia-reperfusion injury via improving mitochondrial fusion/mitophagy and activating the AMPK-OPA1 signaling pathways [J]. J Pineal Res, 2019, 66(2): e12542.
36	Dioszeghy V, Rosas M, Maskrey BH, et al. 12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo [J]. J Immunol, 2008, 181(9): 6514-6524.
37	Glass CK, Saijo K. Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells [J]. Nat Rev Immunol, 2010, 10(5): 365-376.
38	Zhao T, Wang D, Cheranov SY, et al. A novel role for activating transcription factor-2 in 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis [J]. J Lipid Res, 2009, 50(3): 521-533.
39	Wen Y, Gu J, Vandenhoff GE, et al. Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages [J]. Am J Physiol Heart Circ Physiol, 2008, 294(4): H1933-H1938.
40	Reddy MA, Sahar S, Villeneuve LM, et al. Role of Src tyrosine kinase in the atherogenic effects ofthe 12/15-lipoxygenase pathway in vascular smooth muscle cells [J]. Arterioscler Thromb Vasc Biol, 2009, 29(3): 387-393.
41	Halade GV, Kain V, Ingle KA, et al. Interaction of 12/15-lipoxygenase with fatty acids alters the leukocyte kinetics leading to improved postmyocardial infarction healing [J]. Am J Physiol Heart Circ Physiol, 2017, 313(1): H89-H102.
42	Wang AW, Song L, Miao J, et al. Baicalein attenuates angiotensin II-induced cardiac remodeling viainhibition of AKT/mTOR, ERK1/2, NF-κB, and calcineurin signaling pathways in mice [J]. Am J Hypertens, 2015, 28(4): 518-526.
43	Rajesh M, Mukhopadhyay P, Bátkai S, et al. Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy [J]. J Am Coll Cardiol, 2010, 56(25): 2115-2125.
44	Teshima Y, Takahashi N, Nishio S, et al. Production of reactive oxygen species in the diabetic heart. Roles of mitochondria and NADPH oxidase [J]. Circ J, 2014, 78(2): 300-306.
45	Bugger H, Boudina S, Hu XX, et al. Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3 [J]. Diabetes, 2008, 57(11): 2924-2932.
46	Gorin Y, Block K. Nox as a target for diabetic complications [J]. Clin Sci (Lond), 2013, 125(8): 361-382.
47	Dikalov S. Cross talk between mitochondria and NADPH oxidases [J]. Free Radic Biol Med, 2011, 51(7): 1289-1301.
48	Lee SB, Bae IH, Bae YS, et al. Link between mitochondria and NADPH oxidase 1 isozyme for the sustained production of reactive oxygen species and cell death [J]. J Biol Chem, 2006, 281(47): 36228-36235.
49	Frustaci A, Kajstura J, Chimenti C, et al. Myocardial cell death in human diabetes [J]. Circ Res, 2000, 87(12): 1123-1132.
50	Peterson LR, Herrero P, Schechtman KB, et al. Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women [J]. Circulation, 2004, 109(18): 2191-2196.
51	Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death [J]. Cell, 2012, 149(5): 1060-1072.
52	Gao M, Monian P, Quadri N, et al. Glutaminolysis and transferrin regulate ferroptosis [J]. Mol Cell, 2015, 59(2): 298-308.
53	Baba Y, Higa JK, Shimada BK, et al. Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes [J]. Am J Physiol Heart Circ Physiol, 2018, 314(3): H659-H668.
54	李佳, 邓胜利. 内质网应激在心脏的作用 [J]. 辽宁医学杂志, 2015, 29(6): 321-323.
55	Fang X, Wang H, Han D, et al. Ferroptosis as a target for protection against cardiomyopathy [J]. Proc Natl Acad Sci U S A, 2019, 116(7): 2672-2680.
56	Conrad M, Angeli JP, Vandenabeele P, et al. Regulated necrosis: disease relevance and therapeutic opportunities [J]. Nat Rev Drug Discov, 2016, 15(5): 348-366.
57	Yang WS, SriRamaratnam R, Welsch ME, et al. Regulation of ferroptotic cancer cell death by GPX4 [J]. Cell, 2014, 156(1-2): 317-331.
58	Doll S, Proneth B, Tyurina YY, et al. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition [J]. Nat Chem Biol, 2017, 13(1): 91-98.
59	Probst L, Dächert J, Schenk B, et al. Lipoxygenase inhibitors protect acute lymphoblastic leukemia cells from ferroptotic cell death [J]. Biochem Pharmacol, 2017, 140: 41-52.
60	Seiler A, Schneider M, Förster H, et al. Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death [J]. Cell Metab, 2008, 8(3): 237-248.
61	Loscalzo J. Membrane redox state and apoptosis: death by peroxide [J]. Cell Metab, 2008, 8(3): 182-183.
62	Drefs M, Thomas MN, Guba M, et al. Modulation of glutathione hemostasis by inhibition of 12/15-lipoxygenase prevents ROS-mediated cell death after hepatic ischemia and reperfusion [J]. Oxid Med Cell Longev, 2017, 2017: 8325754.
63	Park TJ, Park JH, Lee GS, et al. Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes [J]. Cell Death Dis, 2019, 10(11): 835.

[1]	Shuying Qi, Xiang Li, Fei Liu. Predictive value of glycemic gap for myocardial ischemia reperfusion injury in non-diabetic patients with acute ST-segment elevation myocardial infarction [J]. Chinese Journal of Critical Care Medicine(Electronic Edition), 2021, 14(06): 448-452.
[2]	Hongyu Li, Yanting Liu, Dongsheng Yu. Research progress of ferroptosis and its research prospects in tumor radiotherapy [J]. Chinese Journal of Stomatological Research(Electronic Edition), 2021, 15(06): 325-332.
[3]	Sijia Liu, Xiling Zhang, Cuijun Huang, Yunjian Liu. Ferroptosis in common liver diseases: development of research [J]. Chinese Archives of General Surgery(Electronic Edition), 2022, 16(03): 231-235.
[4]	Jiantao Mo, Peize Yang, Ruiqi Cao, Qingyong Ma, Zheng Wang, Zheng Wu, Cancan Zhou. Establishment of a ferroptosis-related lncRNA prognostic model for patients with intrahepatic cholangiocarcinoma based on bioinformatics analysis [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(02): 185-189.
[5]	Tao Wang, Mengzhou Wang, Jia Zhang. Role of ferroptosis in treatment of hepatocellular carcinoma [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2022, 11(02): 215-217.
[6]	Chengfei Liu, Shaoqiang Xu, Tian Yao, He Huang. Research progress of glutathione in proliferation, metastasis and diagnosis and treatment of colorectal cancer [J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2022, 11(06): 506-510.
[7]	Yanqi Song, Xuejing Ren, Wenjuan Wang, Qiuxia Han, Yue Xu, Kaiting Zhuang, Tuo Xiao, Guangyan Cai. Effect of mesenchymal stem cells on ferroptosis in cisplatin-induced acute kidney injury of mice [J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2023, 12(04): 187-193.
[8]	Yanchen Li, Jianning Li, Xiaowen Tu, Fengsheng Li. Progress of research on the role of ferroptosis in acute kidney injury caused by nuclear radiation [J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2022, 11(06): 338-341.
[9]	Abudurxiti Adilai·, Ao Fei, Xiaowen Xing, Shengqiang Xie, Rui Zhang, Xiaojuan Lan, Gang Cheng. Comparison of injury features of three cell models simulating traumatic brain injury in vitro [J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2023, 09(02): 69-75.
[10]	Shidong Deng, Lingzhi Liu, Dayong Guo, Chao Wang, Zhongxin Huang, Huihui Zhang. Effects of SNHG1 gene silencing on proliferation, apoptosis, migration, and ferroptosis of bladder cancer cells [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(07): 804-811.
[11]	Minjie Zhang, Xiaoshan Zhang, Shasha Duan, Yilu Shi, Jie Zhao, Tianhao Bai, Yaxi Wang. Hydrogen for treatment of myocardial ischemia-reperfusion injury: mechanism and prospect [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(06): 744-748.
[12]	Minjie Zhang, Yaxi Wang, Shasha Duan, Yilu Shi, Wenyan Fu, haiyue Zhao, Xiaoshan Zhang. Bioinformatics screening of potential pathways and targets related to myocardial ischemia-reperfusion injury in rats based on GEO database [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(04): 438-445.
[13]	Ailun Xie, Dongyan Zheng, Ziwei Cai, Renjian Lu, Yongming Peng, He Zhang, Jialong Chen. Rotenone promotes ferroptosis of dopaminergic neurons by reducing the expression of MCU protein [J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2023, 11(02): 71-78.
[14]	Minchang Li, Changlin Ma. Research progress of autophagy regulating cell ferroptosis and the effects of ferroptosis in tumors [J]. Chinese Journal of Diagnostics(Electronic Edition), 2023, 11(02): 140-144.
[15]	Qian Liu, Xin Li, Xin Liu, Jinxiang Yuan. Research progress of ferroptosis in the pathogenesis of Alzheimer′s disease [J]. Chinese Journal of Diagnostics(Electronic Edition), 2022, 10(03): 211-215.

Please choose a citation manager

Content to export