Inflammatory bowel disease (IBD) is a chronic, non-specific intestinal inflammatory disease. Conventional treatment often requires long-term maintenance treatment with related drugs after rapid induction of remission. The safety of drugs is not only the key to achieving long-term maintenance, but also the primary factor for clinical drug discontinuation. Among the known adverse reactions of drugs for the treatment of inflammatory bowel disease, drug-induced pancreatitis is a serious adverse reaction, which often leads to the withdrawal of drugs and affects the treatment of patients with inflammatory bowel disease. In this paper, we summarize the research progress and possible pathological mechanism of drug-induced pancreatitis caused by commonly used drugs for the treatment of inflammatory bowel disease, in order to raise clinician's awareness of the disease and strengthen clinical monitoring.