Characteristics of magnetic resonance imaging proton density fat fraction in patients with metabolic associated fatty liver disease

doi:10.3877/cma.j.issn.1674-0785.2021.07.005

Abstract

Abstract:

Objective

To investigate the characteristics of magnetic resonance imaging proton density fat fraction (MRI-PDFF) in patients with metabolic associated fatty liver disease (MAFLD) and analyze the relationship of MRI-PDFF with abdominal circumference, hip circumference, body mass index (BMI), and liver function.

Methods

A total of 171 infectious outpatients with MAFLD at Jiangsu Province Hospital of Chinese Medicine were recruited from January 2018 to April 2020. The MRI-PDFF, height, weight, abdominal circumference, hip circumference, and serum indexes of liver function (ALT, AST, ALP, and GGT) in all patients were tested.

Results

The MRI-PDFF of the 171 patients was (13.79±10.32) %. As the liver fat content increased, the patients' abdominal circumference, hip circumference, BMI, and liver function levels also gradually increased. The abdominal circumference (F=4.050, P=0.008), hip circumference (F=3.449, P=0.018), BMI (F=3.552, P=0.016), ALT (H=27.904, P＜0.001), AST (H=25.070, P＜0.001), GGT (H=24.039, P＜0.001) differed significantly among different levels of MRI-PDFF. Correlation analysis showed that liver MRI-PDFF was moderately related to ALT (r=0.459, P＜0.001) and AST (r=0.436, P＜0.001), but had a very low correlation with BMI (r=0.149, P=0.052).

Conclusion

MRI-PDFF as a non-invasive and quantitative method can accurately reflect liver fat content, and is suitable for dynamic evaluation of liver fat content and monitoring of treatment effect.

Key words: Magnetic resonance imaging, Proton density fat fraction, Metabolic associated fatty liver disease

Weiting Lu, Huilian Shi, Qinlei Chen, Jianhai Wu, Shaowei Liu, Fei Qiao. Characteristics of magnetic resonance imaging proton density fat fraction in patients with metabolic associated fatty liver disease[J]. Chinese Journal of Clinicians(Electronic Edition), 2021, 15(07): 503-508.

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Figures/Tables 5

组别	例数	腹围（cm， $x ¯$ ±s）	臀围（cm， $x ¯$ ±s）	MRI-PDFF（%， $x ¯$ ±s）	ALT［U/L，M（P₂₅，P₇₅）］	AST［U/L，M（P₂₅，P₇₅）］	ALP（U/L， $x ¯$ ±s）	GGT［U/L，M（P₂₅，P₇₅）］
正常组	13	80.5±3.91	91.79±1.51	10.56±10.98	36（22.00，75.00）	31（22.50，49.00）	83.38±30.92	34（20.00，45.50）
超重组	118	90.80±6.17	99.68±3.85	13.11±9.98	54（31.25，87.75）	35.5（26.25，56.00）	74.47±21.07	44.5（23.25，80.75）
肥胖组	40	111.35±2.34	110.11±4.93	16.72±10.64	75.5（46.25，135.25）	43.5（31.25，58.75）	77.85±21.33	48.5（27.25，66.75）
统计值		F=54.001	F=142.100	F=2.565	H=10.720	H=4.070	F=1.158	H=1.759
P值		＜0.001	＜0.001	0.080	0.005	0.131	0.317	0.415

组别	例数	腹围（cm， $x ¯$ ±s）	臀围（cm， $x ¯$ ±s）	MRI-PDFF（%， $x ¯$ ±s）	ALT［U/L，M（P₂₅，P₇₅）］	AST［U/L，M（P₂₅，P₇₅）］	ALP（U/L， $x ¯$ ±s）	GGT［U/L，M（P₂₅，P₇₅）］
正常组	13	80.5±3.91	91.79±1.51	10.56±10.98	36（22.00，75.00）	31（22.50，49.00）	83.38±30.92	34（20.00，45.50）
超重组	118	90.80±6.17	99.68±3.85	13.11±9.98	54（31.25，87.75）	35.5（26.25，56.00）	74.47±21.07	44.5（23.25，80.75）
肥胖组	40	111.35±2.34	110.11±4.93	16.72±10.64	75.5（46.25，135.25）	43.5（31.25，58.75）	77.85±21.33	48.5（27.25，66.75）
统计值		F=54.001	F=142.100	F=2.565	H=10.720	H=4.070	F=1.158	H=1.759
P值		＜0.001	＜0.001	0.080	0.005	0.131	0.317	0.415

组别	例数	腹围（cm， $x ¯$ ±s）	臀围（cm， $x ¯$ ±s）	BMI（kg/m²， $x ¯$ ±s）	ALT［U/L，M（P₂₅，P₇₅）］	AST［U/L，M（P₂₅，P₇₅）］	ALP（U/L， $x ¯$ ±s）	GGT［U/L，M（P₂₅，P₇₅）］
正常组	49	89.17±8.47	99.05±5.64	25.97±2.88	44（26.00，60.00）	29（25.00，42.00）	76.85±20.51	27（19.0，48.0）
轻度脂肪肝组	29	94.35±9.31	102.12±7.07	27.91±4.08	45（28.50，83.00）	30（24.50，51.00）	75.6±21.03	40（20.0，104.0）
中度脂肪肝组	65	98.91±21.19	102.55±6.77	28.07±4.16	65（34.50，98.00）	42（30.00，55.50）	76.05±23.27	48（28.5，66.5）
重度脂肪肝组	28	95.73±9.25	102.83±6.09	27.68±2.87	101（63.50，159.25）	59（42.25，89.50）	74.46±23.53	76.5（54.5，117.0）
统计值		F=4.050	F=3.449	F=3.552	H=27.904	H=25.070	F=0.071	H=24.039
P值		0.008	0.018	0.016	＜0.001	＜0.001	0.976	＜0.001

组别	例数	腹围（cm， $x ¯$ ±s）	臀围（cm， $x ¯$ ±s）	BMI（kg/m²， $x ¯$ ±s）	ALT［U/L，M（P₂₅，P₇₅）］	AST［U/L，M（P₂₅，P₇₅）］	ALP（U/L， $x ¯$ ±s）	GGT［U/L，M（P₂₅，P₇₅）］
正常组	49	89.17±8.47	99.05±5.64	25.97±2.88	44（26.00，60.00）	29（25.00，42.00）	76.85±20.51	27（19.0，48.0）
轻度脂肪肝组	29	94.35±9.31	102.12±7.07	27.91±4.08	45（28.50，83.00）	30（24.50，51.00）	75.6±21.03	40（20.0，104.0）
中度脂肪肝组	65	98.91±21.19	102.55±6.77	28.07±4.16	65（34.50，98.00）	42（30.00，55.50）	76.05±23.27	48（28.5，66.5）
重度脂肪肝组	28	95.73±9.25	102.83±6.09	27.68±2.87	101（63.50，159.25）	59（42.25，89.50）	74.46±23.53	76.5（54.5，117.0）
统计值		F=4.050	F=3.449	F=3.552	H=27.904	H=25.070	F=0.071	H=24.039
P值		0.008	0.018	0.016	＜0.001	＜0.001	0.976	＜0.001

项目	BMI	腹围	臀围	ALT	AST	ALP	GGT
r值	0.149	0.167	0.178	0.459	0.436	-0.021	0.306
P值	0.052	0.029	0.020	＜0.001	＜0.001	0.788	＜0.001

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