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Chinese Journal of Clinicians(Electronic Edition) ›› 2021, Vol. 15 ›› Issue (07): 503-508. doi: 10.3877/cma.j.issn.1674-0785.2021.07.005

• Clinical Research • Previous Articles     Next Articles

Characteristics of magnetic resonance imaging proton density fat fraction in patients with metabolic associated fatty liver disease

Weiting Lu1, Huilian Shi1, Qinlei Chen1, Jianhai Wu2, Shaowei Liu3, Fei Qiao1,()   

  1. 1. Department of Infectious Diseases, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, China
    2. Department of Nutrition, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, China
    3. Department of Radiology, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, China
  • Received:2021-04-18 Online:2021-07-15 Published:2021-11-09
  • Contact: Fei Qiao

Abstract:

Objective

To investigate the characteristics of magnetic resonance imaging proton density fat fraction (MRI-PDFF) in patients with metabolic associated fatty liver disease (MAFLD) and analyze the relationship of MRI-PDFF with abdominal circumference, hip circumference, body mass index (BMI), and liver function.

Methods

A total of 171 infectious outpatients with MAFLD at Jiangsu Province Hospital of Chinese Medicine were recruited from January 2018 to April 2020. The MRI-PDFF, height, weight, abdominal circumference, hip circumference, and serum indexes of liver function (ALT, AST, ALP, and GGT) in all patients were tested.

Results

The MRI-PDFF of the 171 patients was (13.79±10.32) %. As the liver fat content increased, the patients' abdominal circumference, hip circumference, BMI, and liver function levels also gradually increased. The abdominal circumference (F=4.050, P=0.008), hip circumference (F=3.449, P=0.018), BMI (F=3.552, P=0.016), ALT (H=27.904, P<0.001), AST (H=25.070, P<0.001), GGT (H=24.039, P<0.001) differed significantly among different levels of MRI-PDFF. Correlation analysis showed that liver MRI-PDFF was moderately related to ALT (r=0.459, P<0.001) and AST (r=0.436, P<0.001), but had a very low correlation with BMI (r=0.149, P=0.052).

Conclusion

MRI-PDFF as a non-invasive and quantitative method can accurately reflect liver fat content, and is suitable for dynamic evaluation of liver fat content and monitoring of treatment effect.

Key words: Magnetic resonance imaging, Proton density fat fraction, Metabolic associated fatty liver disease

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