Effect of sequential blood purification combined with naloxone on blood gas parameters, hemorheology, and inflammatory factors in patients with acute poisoning

doi:10.3877/cma.j.issn.1674-0785.2022.03.008

Abstract

Abstract:

Objective

To investigate the effect of sequential blood purification combined with naloxone on blood gas parameters, hemorheology, and inflammatory factors in patients with acute poisoning.

Methods

A total of 102 patients with acute poisoning admitted to 3201 Hospital of Xi'an Jiaotong University from June 2019 to June 2020 were selected and divided into an observation group and a control group according to the treatment method used, with 51 cases in each group. Patients in both groups received conventional treatment. The control group was additionally given naloxone treatment, and the observation group was additionally treated with naloxone combined with sequential blood purification. The therapeutic effects, awakening time, and hospitalization time were compared between the two groups. Blood gas parameters, hemorheology, and inflammatory factors before and after treatment were also compared.

Results

The total effective rate in the observation group was higher than that of the control group (94.12% vs 80.39%, P＜0.05). The awakening time and hospitalization time in the observation group were shorter than those of the control group [(2.46±0.71) h vs (4.72±1.29) h, (7.85±2.12) d vs (10.94±2.53) d, P＜0.05]. After treatment, PaO₂ in both groups was higher than that before treatment, while PaCO₂ and lactic acid levels were lower than those before treatment (P＜0.05); after treatment, PaO₂ in the observation group was higher than that that of the control group, while PaCO₂ and lactic acid levels were lower than those of the control group (P＜0.05). Plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, and hematocrit after treatment were lower than those before treatment in both groups (P＜0.05); these indexes in the observation group were lower than those of the control group after treatment (P＜0.05). The levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-18, and IL-6 after treatment were lower than those before treatment in both groups (P＜0.05); these indexes in the observation group were lower than those of the control group after treatment (P＜0.05).

Conclusion

Sequential blood purification combined with naloxone has a good effect for patients with acute poisoning, which can improve blood gas parameters and hemorheology, and reduce inflammation.

Key words: Sequential blood purification, Naloxone, Acute poisoning, Blood gas analysis, Hemorheology, Inflammatory factors

Fei Xu, Ya Jiang, Chao Liu, Yao Wu, Bing Li. Effect of sequential blood purification combined with naloxone on blood gas parameters, hemorheology, and inflammatory factors in patients with acute poisoning[J]. Chinese Journal of Clinicians(Electronic Edition), 2022, 16(03): 236-240.

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References 20

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组别	例数	显效（例）	有效（例）	无效（例）	总有效率（%）
观察组	51	38	10	3	94.12
对照组	51	27	14	10	80.39
χ²值					4.320
P值					0.038

组别	例数	显效（例）	有效（例）	无效（例）	总有效率（%）
观察组	51	38	10	3	94.12
对照组	51	27	14	10	80.39
χ²值					4.320
P值					0.038

组别	例数	苏醒时间（h）	住院时间（d）
观察组	51	2.46±0.71	7.85±2.12
对照组	51	4.72±1.29	10.94±2.53
t值		10.961	6.685
P值		＜0.001	＜0.001

组别	例数	苏醒时间（h）	住院时间（d）
观察组	51	2.46±0.71	7.85±2.12
对照组	51	4.72±1.29	10.94±2.53
t值		10.961	6.685
P值		＜0.001	＜0.001

组别	例数	PaO₂（mmHg）		PaCO₂（mmHg）		乳酸（mmol/L）
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
观察组	51	40.26±2.97	54.78±3.24^a	56.23±4.82	38.75±4.02^a	1.32±0.25	0.72±0.18^a
对照组	51	40.61±3.85	46.87±4.10^a	57.01±4.21	46.28±3.79^a	1.34±0.31	0.97±0.15^a
t值		0.514	10.810	0.870	9.733	0.359	7.620
P值		0.608	＜0.001	0.386	＜0.001	0.721	＜0.001

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