Advances in application of mineralized collagen in treatment of bone defects

doi:10.3877/cma.j.issn.1674-0785.2023.12.018

Abstract

Abstract:

Bone tissue has a natural regenerative ability, but serious bone defects require certain clinical interventions. The gold standard for clinical repair of various bone defects is bone grafting; however, there are problems such as limited access to natural bone for therapeutic grafting, concurrent infections, and immune rejection. Artificial bone repair materials avoid the above problems to a certain extent and offer greater potential and prospects for application. Mineralized collagen is one of the most biomimetic bone defect repair materials, with the composition and multilevel structure of natural bone, which not only has the ability to treat bone defects by itself, but also can be compounded with other substances, such as polymers, metal ions, and angiogenic and osteogenic factors, to improve its ability to repair bone defects. This paper focuses on the clinical problems of treating bone defects, and summarizes the application of mineralized collagen and repair materials using it as a matrix for treating different bone defects, with an aim to to provide ideas for using mineralized collagen materials for bone defect repair.

Key words: Bone structure, Bone defect, Mineralized collagen, Treatment

Shihang Liu, Shuai Zhou, Shiji Qin, Xiaodong Cheng, Kai Ding, Haicheng Wang, Chao Li, Junli Lu, Hongzhi Lyu. Advances in application of mineralized collagen in treatment of bone defects[J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(12): 1320-1324.

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