Short-term clinical efficacy of 630 nm laser combined with hematoporphyrin derivatives in treatment of advanced bronchial lung cancer

doi:10.3877/cma.j.issn.1674-0785.2024.02.004

Abstract

Abstract:

Objective

To analyze the short-term clinical efficacy and safety of 630 nm laser combined with hematoporphyrin derivatives in the treatment of advanced bronchial lung cancer.

Methods

A total of 43 patients with pathologically diagnosed bronchial lung cancer who underwent interventional tumor reduction combined with treatment with 630 nm laser and hematoporphyrin derivatives, chemotherapy, and immunotherapy were selected at the Affiliated Hospital of Qingdao University from March 2019 to September 2023. The basic clinical features and adverse reactions after treatment were recorded, and chest CT and bronchoscopy were reviewed 1 month after treatment.

Results

Chest CT showed that the tumor volume in the trachea or bronchus was significantly reduced after treatment, and ventilation was improved. Bronchoscopy showed that the tumor volume decreased or even disappeared after treatment. After 1 month of treatment, 31 patients (72.09%) were re-examined by chest CT and bronchoscopy, and the total effective rate was 70.97%. None of the 43 patients had serious complications, but 3 patients had common complications.

Conclusion

630 nm laser combined with hematoporphyrin derivatives has obvious clinical efficacy in the treatment of advanced bronchial lung cancer, and it can improve airway stenosis and relieve dyspnea, cough, and other symptoms with a favorable safety profile.

Key words: 630?nm laser, Hematoporphyrin derivatives, Lung cancer, Photodynamic therapy, Short-term effect

Linyu Li, Shichao Cui, Xiaohui Yang, Yiwei Cao, Cunzhi Lin. Short-term clinical efficacy of 630 nm laser combined with hematoporphyrin derivatives in treatment of advanced bronchial lung cancer[J]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(02): 133-138.

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Figures/Tables 4

References 23

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特征	例（%）
年龄	65.35±9.67
性别
男性	37（86.05）
女性	6（13.95）
治疗方案
PDT+化疗	20（46.51）
PDT+化疗+免疫	9（20.93）
PDT+免疫+化疗+手术	4（9.30）
PDT	4（9.30）
PDT+化疗+靶向	3（6.98）
PDT+免疫	1（2.33）
PDT+靶向	1（2.33）
PDT+化疗+放疗	1（2.33）
病理类型
鳞癌	28（65.12）
腺癌	5（11.63）
小细胞癌	6（13.95）
鳞癌合并腺癌	2（4.65）
类癌	1（2.33）
鳞癌合并液腺癌	1（2.33）
TNM分期
Ⅰ期	1（2.33）
Ⅱ期	1（2.33）
Ⅲ期	14（32.56）
Ⅳ期	21（42.84）
局限期	1（2.33）
广泛期	5（11.63）

特征	例（%）
年龄	65.35±9.67
性别
男性	37（86.05）
女性	6（13.95）
治疗方案
PDT+化疗	20（46.51）
PDT+化疗+免疫	9（20.93）
PDT+免疫+化疗+手术	4（9.30）
PDT	4（9.30）
PDT+化疗+靶向	3（6.98）
PDT+免疫	1（2.33）
PDT+靶向	1（2.33）
PDT+化疗+放疗	1（2.33）
病理类型
鳞癌	28（65.12）
腺癌	5（11.63）
小细胞癌	6（13.95）
鳞癌合并腺癌	2（4.65）
类癌	1（2.33）
鳞癌合并液腺癌	1（2.33）
TNM分期
Ⅰ期	1（2.33）
Ⅱ期	1（2.33）
Ⅲ期	14（32.56）
Ⅳ期	21（42.84）
局限期	1（2.33）
广泛期	5（11.63）

特征	短期疗效
特征	N	CR	PR	SD	PD	（CR+PR+SD）/N（%）
所有患者	31	0	15	7	9	70.97
病理类型
鳞癌	18	0	7	6	4	72.22
腺癌	5	0	2	0	3	40.00
小细胞癌	4	0	3	0	1	75.00
鳞癌合并腺癌	2	0	2	0	0	100.00
类癌	1	0	1	0	0	100.00
鳞癌合并黏液腺癌	1	0	0	0	1	0
TNM分期
Ⅰ期	1	0	1	0	0	100.00
Ⅲ期	10	0	5	4	1	90.00
Ⅳ期	16	0	6	3	7	56.25
局限期	1	0	1	0	0	100.00
广泛期	3	0	2	0	1	66.67

特征	短期疗效
特征	N	CR	PR	SD	PD	（CR+PR+SD）/N（%）
所有患者	31	0	15	7	9	70.97
病理类型
鳞癌	18	0	7	6	4	72.22
腺癌	5	0	2	0	3	40.00
小细胞癌	4	0	3	0	1	75.00
鳞癌合并腺癌	2	0	2	0	0	100.00
类癌	1	0	1	0	0	100.00
鳞癌合并黏液腺癌	1	0	0	0	1	0
TNM分期
Ⅰ期	1	0	1	0	0	100.00
Ⅲ期	10	0	5	4	1	90.00
Ⅳ期	16	0	6	3	7	56.25
局限期	1	0	1	0	0	100.00
广泛期	3	0	2	0	1	66.67

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